COX-2,VEGF在子宫内膜异位症组织中的表达及相关性

目的:探讨环氧化酶-2(COX-2)和血管内皮生长因子(VEGF)在子宫内膜异位症(EMs)组织中的表达与生物学行为的相关性. 方法:采用免疫组织化学法对32例EMs患者组织中COX-2和VEGF的表达进行检测. 结果:32例EMs,患者组织中COX-2和VEGF的阳性表达率分别为84.3%和93.8%,较正常内膜的表达明显增高(P<0.001). 在位内膜、异位内膜的COX-2和VEGF在增殖期和分泌期分别为83.3%, 85.7%和94.4%, 92.9%,差异不显著(P>0.05). COX-2表达与VEGF的表达有一定相关性(r=0.747,P<0.001).结论:COX-2和VEGF在EMs的发生、发展中起着关键性作用,二者在血管生成过程中密切相关,可能为EMs的治疗提供新的靶点.

COX-2 expression and its correlation with VEGF in endometriosis

AIM: To investigate the expression of cyclooxygenase 2 (COX 2) and vascular endothelial growth factor (VEGF) in endometriosis and their correlation with clinicalbiological behavior, and to probe the possible mechanism of their association. METHODS: The expression of COX 2 and VEGF in 32 cases of endometriosis patients was detected by immunohistochemistry methods. RESULTS: The expression of COX 2 and VEGF in endometriosis was 84.3% and 93.8%, respectively, which was significant higher than that of normal endometriosis ( P <0.001). COX 2 and VEGF of eutopic and ectopic endometrium in proliferative phase and secretory phase were 83.3%, 85.7% and 94.4% , 92.9%. The expression of COX 2 was closely correlated with that of VEGF ( r =0.747, P <0.001). CONCLUSION: COX 2 and VEGF may play a key role in endometriosis. Both may have close relation in angiogenesis and may provide new targets for therapy of endometriosis.