| PHA对小鼠H_(22)腹水癌细胞DNA和RNA合成以及体外生长的影响 |
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| 引用本文： | 吉昌华,梁延春,王字玲,李方,程芮,闰岩,吴智群,张岚.PHA对小鼠H_(22)腹水癌细胞DNA和RNA合成以及体外生长的影响[J].第四军医大学学报,1988(6). |
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| 作者姓名： | 吉昌华 梁延春 王字玲 李方 程芮 闰岩 吴智群 张岚 |
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| 作者单位： | 第四军医大学生物化学教研室
(吉昌华)，第四军医大学1984年级
(梁延春，王字玲，李方，程芮，闰岩，吴智群)，第四军医大学1984年级(张岚) |
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| 摘 要： | PHA对小鼠H_(22)腹水癌细胞DNA和RNA合成以及体外生长均有显著的抑制效应,且具有时间和剂量相关性。在任一时间和剂量下,PHA对癌细胞的抑制均强于正常细胞。PHA对癌细胞的凝集作用比正常细胞强32倍。
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| 关 键 词： | 植物血凝素 H_(22)腹水癌细胞 脱氧核糖核酸 肿瘤 核糖核酸 肿瘤 细胞毒性 |
Effects of Phytohemagglutinin on DNA and RNA Synthesis and in Vitro Growth of Mouse H22 Ascitic Tumor Cells |
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| Ji Changhua,Liang Yanchun,Wang Zilin,Li Fang,Cheng Rui,Yan Yan,Wu Zhiqun and Zhang Lan.Effects of Phytohemagglutinin on DNA and RNA Synthesis and in Vitro Growth of Mouse H22 Ascitic Tumor Cells[J].Journal of the Fourth Military Medical University,1988(6). |
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| Authors: | Ji Changhua Liang Yanchun Wang Zilin Li Fang Cheng Rui Yan Yan Wu Zhiqun and Zhang Lan |
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| Institution: | Ji Changhua,Liang Yanchun,Wang Zilin,Li Fang,Cheng Rui,Yan Yan,Wu Zhiqun and Zhang LanDepartment of Biochemistry Grade 1984 |
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| Abstract: | The strong inhibitory effects of kidney bean phytohemagglutinin (PHA) have been revealed on DNA and RNA synthesis and in vitro growth of mouse H22 ascitic tumor cells. These effects are highly time-related and dose-related. At any time or dose, PHA causes a stronger inhibition on tumor cells than normal cells. And the agglutination titre of PHA to tumor cells is 32 times more than that to normal cells. |
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| Keywords: | phytohemagglutinins H2 ascites carcinoma DNA neoplasm RNA neoplasm cytotoxity |
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