2009年秋季北京市3家哨点医院甲型HIN1流感病毒监测结果特征分析

目的回顾分析2009年秋季北京市3家哨点医院甲型H1Nl流感监测结果，为科学防控提供指导。方法回顾分析2009年5月8日～12月31日北京市西城区、海淀区、朝阳区3家哨点医院对甲型H1N1流感病毒监测情况，共计2632例流感样病例入选。其中，男性1418例，女性1214例，年龄1～98岁；采用real-timePCR方法对人选病例咽拭子标本进行甲型HIN1病毒核酸检测，同时全血细胞计数仪检测血常规。结果2632例流感样病例中，甲型H1N1流感病例占流感样调查人群的14．7％。其中，男性H1N1病例占其调查人群的15％，女性H1N1病例占其调查人群的14．3％，二者统计学无显著性差异（P〈0．01）。易感人群以7～18岁中小学生为主（占甲型H1N1流感病例的53．4％）；5～7月份甲型HlNl流感病例以输入性病例为主（占同期甲型H1N1流感病例的88．5％），9、10月份多起聚集性疫情致本地感染病例达到高峰（占甲型H1N1流感病例的37．2％）；甲型川N1流感病例主要以发热（98％），咳嗽（95％），喉咙痛（81％），流涕（76％）为主要症状就诊，甲型H1N1流感组与病毒检测阴性组比较，H1Nl患者白细胞总数与血小板计数明显偏低，差异具有统计学意义。而与非HlNl型甲型流感组比较，血常规各指标无显著性差异（P〉0．05）。结论本次甲型H1N1流感的临床表现及血常规检查与普通季节性流感相似，北京地区9、10月份是其最适流行季节，最适温度范围12～23℃，7～18岁中小学生是主要防控对象。

Pandemic HIN1 Influenza Surveillance of Three Sentinel Hospitals in Beijing in Autumn 2009.

Objective To retrospectively analyze surveillance date of pandemic H1N1 influenza, in order to apply the measures of prevention. Methods We retrospectively analyzed the monitoring results of H1N1 influenza virus of three sentinel hospitals in Beijing from May 2009 to December 2009. A total of 2632 cases of influenza - like illness were selected, including 1418 male cases from 1 - 98 years old, and 1214 female cases from 1 -98 years old. Influenza A H1N1 was verified by RT- PCR method. The characteristics of peripheral blood was analyzed with complete blood counting instrument by flow eytometry technology. Results In 2632 influenza - like cases, the incidence of H1N1 influenza was 14.7% , and there was no difference in incidence between male and female （ P 〈 0.01 ）. The great majority（53.4% ） of cases were documented among school age children（7 - 18 years old）. From May to July, the imported case predominated in H1 N1 influenza cases （88.5 % ）. From September to October, local infection rised and predominated because of mass epidemic. The mainly clinical symptoms of H1 N1 influenza cases were fever （ 98 % ） , cough （ 95 % ） , sore throat （ 81% ） , rhinorrhea （76%）. WBC count and the total number of platelets in influenza A H1N1 group were significantly lower comparing with virus - negative group. The blood analysis results of HI N1 influenza cases was of no significant difference with non -H1 N1 influenza A （P 〉 0.05）. Conclusion Influenza A H1 N1 is similar to the ordinary seasonal flu in clinical presentation and the characteristics of peripheral blood. The best epidemic season is September to October in Beijing. The best temperature is 12 -23°C. The students of 7-18 years old are the main object to prevent and control.