| 复方氧氟沙星乳膏的主要药效学研究 |
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| 引用本文： | 王贵林,黄先菊,雷元卫,朱慧玲,张燕翔.复方氧氟沙星乳膏的主要药效学研究[J].湖北省卫生职工医学院学报,2004,17(4):7-8. |
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| 作者姓名： | 王贵林 黄先菊 雷元卫 朱慧玲 张燕翔 |
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| 作者单位： | 长江大学医学院，湖北荆州434000 |
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| 摘 要： | 目的：探讨复方氧氟沙星乳膏(COTAC)对小鼠慢性皮炎-湿疹的作用。方法：用7％二硝基氯苯(DNCB)外涂于小鼠背部致敏，5d后用0．1％DNCB于小鼠右耳内侧反复激发，引起慢性皮炎模型，给药组于激发后涂抹COTAC。结果：COTAC能减轻鼠耳肿胀度，减少结痂动物数及浸润炎症细胞数。结论：COTAC能抑制小鼠慢性皮炎-湿疹。
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| 关 键 词： | 氧氟沙星 复方 药效学 皮炎 湿疹 |
The Main Pharmacodynamic Study of Compound Ofloxacin and Triamcinolone Acetonide Cream |
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| Wang Gui-lin,Huang Xian-ju,Lei Yuan-wei,Zhu Hui-ling,Zhang Yan-xiang.The Main Pharmacodynamic Study of Compound Ofloxacin and Triamcinolone Acetonide Cream[J].Journal of Hubei Medical Staff College,2004,17(4):7-8. |
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| Authors: | Wang Gui-lin Huang Xian-ju Lei Yuan-wei Zhu Hui-ling Zhang Yan-xiang |
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| Abstract: | Objective:To investigate actions of Compound Ofloxacin and Tiamcinolone Acetonide Cream (COTAC) on the model of chronic dermatitis-eczema in mice. Methods:Right ears of mice were repeatedly challenged with 0.1% dinitrochlorobenzen(DNCB)every three days for four times with previously sensitized with 7% DNCB to induce the model. COTAC were applied to a group of mice after each challenge. Results:Ear swelling thickening,crusts and inflammatory cellular infiltrates in mice of COTAC group were less obvious than in mice of the model group. Conclusions: COTAC can inhibit chronic dermatitis-eczema in mice. |
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| Keywords: | Ofloxacin Compound Pharmacodynamics dermatitis eczema |
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