非甾体类药物致急性胃粘膜病变的临床表现与内镜特征

目的:探讨非甾体类药(NSAIDs)致急性胃粘膜病变的临床表现及内镜特点。方法:回顾性分析54例NSAIDs导致急性胃粘膜病变患者的临床资料。结果:服用NSAIDs后临床表现为上腹痛,返酸、嗳气者32例(593%)、呕血8例(14.8%)、黑便25例(46.3%)、呕血伴血便10例(18.5%)。内镜下表现为弥漫性胃粘膜充血、水肿及多发性糜烂49例(90.7%),伴应激性浅表溃疡23例(42.6%)。结论:NSAIDs是急性胃粘膜病变的重要病因,对于需长期服用NSAIDs的高危患者,既往有溃疡病史,年龄>60岁,同时服用两种以上NSAIDs或与糖皮质激素同服者应给予预防性治疗。

Clinical Presentation and Endoscopic Characteristics of Acute Gastric Mucosal Lesions (AGML) caused by Non-steroid Anti-inflammatory Drugs (NSAID)

Objective: To investigate the clinical presentation and endoscopic characteristics of AGML caused by NSAID. Methods: The clinical data of 54 patients with AGML caused by NSAID were analyzed by review. Results: Of all patients receiving NSAIDS, 32(59.3%) had upper abdominal pain. 8(14.8%) had hematemesis, 25(46.3%) had tarry stools. 10 had both hematemesis and tarry stool. For endoscopic characteristic, 49(90.7%) had disseminated hyperemia. Edema multiple erosion in gastric mucosa, 23(42.6%) had stress ulcer. Conclusion: NSAIDS were the important factors of AGML. For the patients who took NSAIDS, if they had ulcer history, were older than 60 years, took 2 or more kinds NSAIDs, they should be preventively treated.