活血潜阳颗粒对自发性高血压大鼠血液流变学及纤溶系统活性的影响

目的探讨活血潜阳颗粒对自发性高血压大鼠(SHR)血液流变学、纤溶系统活性的影响。方法SHR 72只,随机分为活血潜阳颗粒大、中、小剂量组及卡托普利组、松龄血脉康组、双蒸水组,并以正常血压Wistar(WKY)大鼠为对照组,给药10周后检测各组大鼠血液流变学指标、血浆组织型纤溶酶原激活物(t-PA)及其抑制物(PAI)。结果与正常WKY大鼠比较,SHR全血黏度、血浆黏度、红细胞聚集指数均明显升高,而经活血潜阳颗粒治疗后上述各项指标较SHR组有不同程度改善(P<0.05或P<0.01)。SHR PAI升高、t-PA降低,经活血潜阳颗粒灌服后PAI降低、t-PA升高(P<0.05或P<0.01)。结论活血潜阳颗粒对自发性高血压大鼠血液流变学、纤溶系统活性具有调节作用。

Effect of Huoxueqianyang granule on hemorrheology and activity of fibrinolytic system in spontaneously hypertensive rats

Objective To investigate the effeet of Huoxueqianyang granule on hemorrheology and activity of fibrinolytic system in spontaneously hypertensive rats（SHR）. Methods Seventy-two SHR were divided into 6 experimental groups randomly, included, distilled water group, Songlingxuemaikang （ SLXM ） treatment grpup, Captopril treatment group, Huoxueqianyang granule treatment group with large, moderate or low dosage groups, and Wistar-Kyoto（WKY） rats were enrolled as normal blood pressure control group. The indexes of hemorheology,tissue activator of plasminogen activator activity （t-PA）, plasminogen activator 1 inlhibitor activity （PAI） were detected after 10 weeks in all groups. Results Compared with WKY control rats,the amounts of the blood viscosity,plasma viscosity,indexes of erythrocyte aggregation were higher in SHR. However, the indexes listed above were improved obviously in Huoxueqianyang granule treatment group （ P 〈 0.01 or P 〈 0.05 ）. Conclusion It suggested that the traditional Chinese medicine Huoxueqianyang granule could improve the indexes of hemorrheology, and regulate the activity of fibrinolytic system.