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| Expression and Prognostic Significance of Livin in the Progression of Bladder Cancer | |
| 作者姓名： | 朱朝辉 王艳波 丁小博 曾甫清 徐凯 |
| 作者单位： | Department of Urology Union Hospital Tongji Medical College Huazhong University of Science and Technology，Department of Urology Union Hospital Tongji Medical College Huazhong University of Science and Technology，Department of Nuclear Medicine the Second Affiliated Hospital of Harbin Medical University，Department of Urology Union Hospital Tongji Medical College Huazhong University of Science and Technology，Department of Otorhinolaryngology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology，Wuhan 430022 China，Wuhan 430022 China，Harbin 150000 China，Wuhan 430022 China，Wuhan 430030 China |
| 摘 要： | It has been suggested that progression of bladder transitional cell cancer (BTCC) may be regulated at the molecular level by a typical pattern of expression of genes involved in apoptosis. Re-cently Livin, belonging to the inhibitors of apoptosis (IAP) family, has been found to be expressed in most solid tumors, where its expression is suggested to have clinical significance. In order to explore the significance of Livin expression in the development of BTCC, immunohistochemistry and RT-QPCR were used to detect the expression of Livin mRNA in tumor tissues and adjacent normal tissues of 30 cases of BTCC. The results showed that the positive rate of Livin expression in adjacent normal tissues and tumor tissues was 0 and 60% (18/30) respectively. The -△△CT value of Livin in BTCC tissues was 8.0454 (7.4264-8.6644) times of that in adjacent normal tissues. The expression of Livin mRNA had no correlation with tumor pathological grades and clinical stages. It was sug-gested that there was weak expression of Livin mRNA in adjacent normal tissues, but strong in tumor tissues. |
| 关 键 词： | 膀胱癌 免疫化学 治疗方法 定量检测 |
| 收稿时间： | 15 January 2007 |
Expression and prognostic significance of livin in the progression of bladder cancer |
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| Zhaohui?Zhu,Yanbo?Wang,Xiaobo?Ding,Fuqing?Zeng,Kai?Xu.Expression and Prognostic Significance of Livin in the Progression of Bladder Cancer[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2008,28(1):90-92. | |
| Authors: | Zhaohui Zhu Yanbo Wang Xiaobo Ding Fuqing Zeng Kai Xu |
| Institution: | 1. Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China 2. Department of Nuclear Medicine, the Second Affiliated Hospital of Harbin Medical University, Harbin 150000, China 3. Department of Otorhinolaryngology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430030, China |
| Abstract: | It has been suggested that progression of bladder transitional cell cancer (BTCC) may be regulated at the molecular level by a typical pattern of expression of genes involved in apoptosis. Re- cently Livin, belonging to the inhibitors of apoptosis (IAP) family, has been found to be expressed in most solid tumors, where its expression is suggested to have clinical significance. In order to explore the significance of Livin expression in the development of BTCC, immunohistochemistry and RT-QPCR were used to detect the expression of Livin mRNA in tumor tissues and adjacent normal tissues of 30 cases of BTCC. The results showed that the positive rate of Livin expression in adjacent normal tissues and tumor tissues was 0 and 60% (18/30) respectively. The -△△CT value of Livin in BTCC tissues was 8.0454 (7.4264-8.6644) times of that in adjacent normal tissues. The expression of Livin mRNA had no correlation with tumor pathological grades and clinical stages. It was sug- gested that there was weak expression ? Livin mRNA in adjacent normal tissues, but strong in tumor tissues. |
| Keywords: | Livin bladder cancer real-time quantitative PCR immunohistochemistry |
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