醒脑静联合尼莫地平治疗急性脑梗死的临床疗效观察

目的观察醒脑静联合尼莫地平治疗急性脑梗死的临床疗效。方法筛选急性脑梗死患者125例,按脑梗死严重程度分层(轻度65例、中重度60例),每层再随机分为观察组和对照组。观察组给予醒脑静加尼莫地平,对照组给予醒脑静加生理盐水。比较两组的神经功能缺损评分和临床疗效。结果治疗两周后,观察组和对照组的神经功能缺损评分均降低,观察组显效率(66.7%)明显高于对照组(40.3%),差异有统计学意义(P<0.01);且轻度脑梗死患者的显效率高于中重度患者,差异有统计学意义(P<0.05)。观察组和对照组不良反应发生率分别为6.3%、1.6%。结论醒脑静联合尼莫地平能有效提高治疗急性脑梗死(尤其是轻度脑梗死患者)的疗效,且未发现安全性问题,值得在临床中推广。

Efficacy of awaking brain injection combined with nimodipine in treatment of acute cerebral infarction

Objective To evaluate the efficacy of awaking brain injection combined with nimodipine in treatment of acute cerebral infarction.Methods According to the cerebral infarction level,a total of 125 patients with acute cerebral infarction were divided into two groups:mild group(n=65) and mid-severe group(n=65),randomly received nimodipine and awaking brain injection(Group I),physiological saline and awaking brain injection(Group II) respectively.Before and after treatment,the neurological deficits were assessed.Results The neurological function impairment of two groups was significantly improved after treatment.The significant efficiency of Group I was 66.7%,and that of Group II was 40.3%.There was significant difference between the two groups(P<0.01).The same results were presented by the comparison between mild group and mid-severe group(P<0.05).The incidence of adverse reaction in Group I and Group II were 6.3% and 1.6% respectively.Conclusion Awaking brain injection combined with nimodipine can effectively and safely improve the neurological dysfunction after acute cerebral infarction,especially mild cerebral infarction,and it is worth of popularizing in clinic.