| 缺血后处理对减小猪急性心肌梗死面积的作用 |
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| 引用本文： | 孙海梅,郭涛,喻卓,许汪斌,窦兴葵,孟照辉.缺血后处理对减小猪急性心肌梗死面积的作用[J].重庆医学,2010,39(5). |
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| 作者姓名： | 孙海梅 郭涛 喻卓 许汪斌 窦兴葵 孟照辉 |
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| 作者单位： | 昆明医学院第一附属医院ICU,昆明,650101;昆明医学院第一附属医院心内科,昆明,650032;昆明医学院第二附属医院麻醉科,昆明,650101 |
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| 基金项目： | 云南省应用基础研究面上项目基金资助(2007C243M) |
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| 摘 要： | 目的探讨缺血后处理限制猪心肌梗死范围的作用。方法滇南小耳猪10只,随机分为2个组。实验组(n=5):在X线的监控下,经右股动脉置入冠状动脉球囊导管至左前降支,球囊扩张阻断血流60min,予8次球囊放气30s、充气30s短暂缺血再灌注即缺血后处理;对照组(n=5):不行缺血后处理,直接撤除球囊。测定缺血前、再灌注2h及24h心肌酶学指标。再灌注72h采用2,3,5氯化三苯基氯四氮唑(TTC)染色确定心肌梗死面积。结果再灌注后2h,两组的磷酸肌酸激酶(CK)及乳酸脱氢酶(LDH)较缺血前明显增高,差异有统计学意义(P<0.05);再灌注后24h,实验组的CK、LDH较对照组明显降低,差异有统计学意义(P<0.05)。病理学检查显示缺血后处理组梗死面积明显小于对照组,差异有统计学意义(P<0.05)。结论缺血后处理有缩小猪急性心肌梗死面积的保护作用。
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| 关 键 词： | 缺血后处理 心肌梗死 猪 |
Effects of ischemic postcondition on reduction of infarction size in swine model of acute myocardial infarction |
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| SUN Hai-mei,GUO Tao,YU Zhuo,et al..Effects of ischemic postcondition on reduction of infarction size in swine model of acute myocardial infarction[J].Chongqing Medical Journal,2010,39(5). |
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| Authors: | SUN Hai-mei GUO Tao YU Zhuo |
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| Institution: | 1.Department of ICU;First Affiliated Hospital of Kunming Medical College;Kunming 650032;China;2.Department of Cardiology;3.Department of Anesthesiology;Second Affiliated Hospital of Kunming Medical College;Kunming 650101;China |
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| Abstract: | Objective To investigate the effects of ischemic postcondition on the reduction of infarction size in the swine model of acute myocardial infarction.Methods Ten Diannan small-ear pigs were divided into study group(n=5) and control group(n=5) randomly.A balloon catheter was positioned in the mid-distal left anterior descending (LAD) via right femoral artery under fluoroscopic guidance.The balloon was inflated and occluded LAD for 60 min.In study group,ischemic postconditioning was elicited by eight cycles of... |
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| Keywords: | ischemic postconditioning myocardial infarction swine |
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