山莨菪碱对实验性脑损害所致认知障碍的改善作用

用自行建立的大鼠内侧额叶皮层损伤和急性脑缺血再灌流损伤两种手术方法，能造成动物学习和记忆的缺陷并可作为“痴呆”模型。从手术当天起，用山莨菪碱（６５４～２）（３０ｍｇ．ｋｇ~（－１）／ｄ，ｉｐ）慢性给药共１０次。首次发现６５４－２对两种脑损害所致的动物对回避反应学习和记忆能力的下降都有改善作用。实验结果还表明，６５４－２能增强皮层损伤后前脑超氧化物岐化酶（ＳＯＤ）的活力，并抑制脂质过氧化物（ＭＤＡ）含量的升高。提示６５４－２可能有抗自由基损伤和保护脑细胞的作用。

Anisodamine(654-2)Improves Impaired Cognitive Function Induced by Experimental Brain Damage

Surgery of brain injury was established in rats with medial frontal cortex lesion or acute cerebral ischemia and reperfusion,Learning and memory deficits were induced.These rats can be served as the animal model of dementia.Intraperitoneal injection of 654-2(30 mg/kg per day)started from the day of surgery until a total of 10 shots were given.We first reported that 654-2 improved the deficits of learning and memory in avoidance response of rats after the two types of brain damage,Further more,the results showed that 654-2 enhanced SOD activity and inhibited the elevation of superoxides(MDA)in forebrain of cortex-lesioned rats.results suggest that 654-2 probably has the effect of protection of the brain cell against the injury of free radicals.