2型糖尿病患者尿微量白蛋白与颈动脉内膜中层厚度的相关性分析

目的探讨2型糖尿病患者尿微量白蛋白与颈动脉内膜中层厚度(IMT)的相关性。方法采用高分辨彩色多普勒测量不同水平尿微量白蛋白排泄率(UAER)的2型糖尿病患者颈动脉IMT;放免法测定UAER。结果微量白蛋白尿组颈动脉IMT较单纯糖尿病组、正常对照组显著增厚(0.89±0.21)mm、(0.74±0.16)mm、(0.62±0.06)mm,P<0.01],单纯糖尿病组颈动脉IMT较正常对照组稍增厚P<0.05。糖尿病患者UAER与颈动脉IMT成显著正相关(r=3.21、P<0.01)。结论尿微量白蛋白增高的糖尿病患者存在动脉粥样硬化,UAER可作为糖尿病患者早期动脉粥样硬化的筛查和评估指标之一。

Research on the relationship between microalbuminuria and carotid intima-media thickness in patients with type 2 diabetes mellitus

Objective To explore the relationship between microalbuminuria and carotid intima-media thickness(IMT) in patients with type 2 diabetes mellitus. Methods This study included 25 healthy subjects (control group) and 74 patients with type 2 diabetes mellitus,diabetic patients were divided into 2 groups according to their urinary alburmin excretion rate(UAER):46 patients with normal UAER(SDM group),28 patients with microalbuminuria(EDN group).Carotid IMT and UAER were measured in all subjects. Results Cartiod IMT increased in the control group subjects,in the SDM group patients,and in the EDM group patients. UAER was positively correlated with cartiod IMT in the patients with diabetes mellitus. Conclusion Microalbuminuria may be a specific indicator of early atherosclerosis in patients with diabetes mellitus.