| 鼻咽癌诊断和治疗的新标志物 |
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| 引用本文： | 唐发清,李建国,谢春蕾,黄大毛,吴苑,曾茂,易伦朝,廖遇平,杨力芳,曹亚,梁逸增.鼻咽癌诊断和治疗的新标志物[J].中国现代医学杂志,2010,20(14). |
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| 作者姓名： | 唐发清 李建国 谢春蕾 黄大毛 吴苑 曾茂 易伦朝 廖遇平 杨力芳 曹亚 梁逸增 |
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| 作者单位： | 暨南大学医学院第三附属医院;中南大学湘雅医院;中南大学化学化工学院;中南大学肿瘤研究所; |
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| 基金项目： | supported by National Natural Science Foundation of China(No:30572455,30973400); Program for New Century Excellent Talents in University,NCET(No:NCET-06-0685); Traditional Chinese Medicine Foundation of Hunan(No:2008039); Science and Technology Foundation of Hunan(No:08FJ3176); Science Foundation of Central South University(No:08SDF07) |
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| 摘 要： | 目的采用代谢组学技术寻找鼻咽癌诊断和治疗的标志物。方法采用气-质联用(GS-MS)技术,检测了49例鼻咽癌患者(Ⅰ期19例,Ⅱ期17例,Ⅲ期13例),37例喉癌患者和40个健康人血清中52种内源性代谢物。结果代谢谱比较分析结果显示,犬氨酸、N-乙酰葡萄酰胺、硬脂酸、甘氨酸、N-乙酰半乳糖胺、N-乙酰葡萄胺和对羟基丙酮酸在鼻咽癌患者血清中显著升高(～3倍)(P<0.05),其中犬氨酸、N-乙酰葡萄酰胺、N-乙酰半乳糖胺、N-乙酰葡萄胺和对羟基丙酮酸在鼻咽癌Ⅰ到Ⅲ逐步升高(P<0.05),治疗后该5种内源性代谢物逐步降低,且恢复到正常水平(P<0.05)。其中4种代谢物犬氨酸、N-乙酰葡萄酰胺、N-乙酰葡萄胺和对羟基丙酮酸水平降低与鼻咽癌治疗后肿瘤减小率成正相关,因此其可作为鼻咽癌潜在标志物。此外,这4个代谢物还与鼻咽癌复发转移有关。结论犬氨酸、N-乙酰葡萄酰胺、N-乙酰葡萄胺和对羟基丙酮酸是鼻咽癌变和侵袭重要的代谢产物。
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| 关 键 词： | GS-MS 鼻咽癌 标志物 |
Novel potential markers of nasopharyngeal carcinoma for diagnosis and therapy |
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| TANG Fa-qing,LI Jian-guo,XIE Chun-lei,HUANG Da-mao,WU Yan,ZENG Mao,YI Lun-chao,LIAO Yu-ping,YANG Li-fang,CAO Ya,LIANG Yi-zeng.Novel potential markers of nasopharyngeal carcinoma for diagnosis and therapy[J].China Journal of Modern Medicine,2010,20(14). |
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| Authors: | TANG Fa-qing LI Jian-guo XIE Chun-lei HUANG Da-mao WU Yan ZENG Mao YI Lun-chao LIAO Yu-ping YANG Li-fang CAO Ya LIANG Yi-zeng |
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| Institution: | TANG Fa-qing1,LI Jian-guo2,XIE Chun-lei2,HUANG Da-mao2,WU Yan2,ZENG Mao3,YI Lun-chao3,LIAO Yu-ping2,YANG Li-fang4,CAO Ya4,LIANG Yi-zeng3(1.Department of Clinical Laboratory,the Third Affiliated Hospital of Jinan University,Zhuhai,Guangdong 519000,P.R.China,2.Xiangya Hospital,Central South University,Changsha,Hunan 410078,3.College of Chemistry and Chemical Engineering,Hunan 410083,4.Cancer Research Institute of Central South University,Hunan 410... |
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| Abstract: | |
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| Keywords: | metabonomics gas chromatography-mass spectrometry principal component analysis nasopharyngeal carcinoma |
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