卵巢浆液性肿瘤组织中端粒酶活性表达临床意义

目的研究端粒酶活性表达在卵巢肿瘤诊断和鉴别诊断方面的意义.方法应用原位杂交检测40例卵巢浆液性肿瘤组织(良性组织20例,交界性肿瘤5例,恶性肿瘤15例)的端粒酶TERT蛋白表达状况.结果20例卵巢良性组织中测出端粒酶TERT表达1例,占5%,5例交界性肿瘤组织中,3例(60%)TERT蛋白呈阳性表达,15例恶性肿瘤组织中,14例(93.3%)TERT蛋白呈阳性表达.结论端粒酶TERT蛋白表达的检测有助于卵巢肿瘤性质的诊断和鉴别诊断.

Clinical signifinace of telomerease activity in human ovarian serous tumor

Objective:To find out the clinical signficance of telomerease activity in diagnosis and differential diagnosis of ovarian serous tumor.Methods:In situ hybridization was used to detect telomerease TERT protein expression in 40 cases of ovarian serous tumor tissues (benign tissue from 20 cases, borderline tissue from 5 cases and malignant tissue from 15 cases).Results:Telomerease activity was detected in 5% of benign tissue (1 case), 60% of borderline tissues (3 cases) and 93.3% of malignant tissue (14 cases).Conclusions:Telomerease TERT protein expression may do help to diagnosis and differential diagnosis of ovarian serous tumor.