黄芩对大鼠胚胎致畸作用的观察

目的 了解黄芩对SD大鼠胚胎的影响。方法妊娠的雌性SD大鼠随机分成阴、阳性组及高、中、低剂量组，每组15只，称重和编号。孕鼠于妊娠7～16d灌胃染毒，20d处死，分析胚胎发育指标与胎仔发育指标，检查有无外观畸形和骨骼畸形。结果与阴性对照组比较，黄芩各实验组孕鼠体重增长未见显减慢，活产仔数未见显减少，死胎率和吸收胎率未见显增加，胎仔平均体重、体长、尾长发育指标未见显减缓，外观畸形和骨骼畸形未见显增加。结论在本实验剂量与条件下黄芩无母体毒性、胚胎毒性、发育毒性和致畸作用。

Observations of Teratogenic Effects of Scutellaria Baicalensis Georgi on Embryos of Rats

Objective To study teratogenic effects of Scutellaria baicalensis Georgi on embryos of SD rats. Method Gravid femals SD rats were randomly divided into five groups, then weighed and tagged. They were administered from 7 through 16 days of their gestation. The rats were weighed and killed on the 20th day of the gestation, embryonic developmental parameters and fetal developmental parameters were analysed, external and skeletal anomalies were examined. Results No significant differences were observed between the Scutellaria baicalensis Georgi dosage groups and the negative control group in body weight gain in pregnant rats. And there were no reduction of number of survivals at birth, no increment of incidence of stillbirth, no decrement of mean body weight, body length and tail length, no retardation of skeletal development, no increment of incidence of external and skeletal anomalies in the fetuses of experimental groups. Conclusion Scutellaria baicalensis Georgi has no maternal toxicity, embryonic and developmental toxicity and teratogenicity under the experimental conditions.