常州地区女性人乳头瘤病毒感染基因亚型分析

目的了解常州地区女性人乳头瘤病毒（HPV）感染基因亚型分布及年龄特点。方法利用基因芯片技术，对来我院就诊的4600例女性进行生殖道HPV基因亚型分析。结果HPV总感染率为22．52％，其中高危亚型感染占总感染的78-34％；多重感染占总感染的32．72％，以双重感染多见。常见的5种高危亚型为HPVl6，52，58，51，39型，常见的2种低危亚型为HPV54，6型。51岁-60岁感染率较高。结论常州地区女性HPV感染率较高，且多重感染率高，年龄以50岁-60岁高发。

Analysis of the human papillomavirus genotyping of female in Changzhou

Objective To investigate the distribution and age characteristics of the genetic subtypes of human papillomavirus （HPV） infection in women in Changzhou. Methods A study was performed involving a sample of 4600 women from our hospital. Gene chips were used to detect of HPV-DNA in cervical specimens. Results The positive rate of HPV infection was 22.56%, among which high-risk genotype rate was 78.34%. Multiple genotype infection rate was 32.72%, among which double was the most common type. The five most common high-risk subtypes were HPV16, 52, 58, 51, 39 and two most common low-risk subtypes were HPV54, 6. There was relatively high infection rate among 51-60 years old women. Conclusion The infection rate of HPV is high in Changzhou. Multiple infection accounts for relatively large ratio. Age 50-60 is high-risk stage of HPV infection for women.