| 无毛小鼠同类系的建立 |
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| 引用本文： | 章金涛,康巧珍,杜献堂,杜春燕,王纯耀,祝庆蕃.无毛小鼠同类系的建立[J].郑州大学学报(医学版),2002,37(2):174-176. |
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| 作者姓名： | 章金涛 康巧珍 杜献堂 杜春燕 王纯耀 祝庆蕃 |
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| 作者单位： | 河南省实验动物中心,郑州,450052 |
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| 基金项目： | 河南省自然科学基金资助项目 2 0 0 40 2 0 90 0，国家自然科学基金资助项目 3 9970 119 |
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| 摘 要： | 目的：培育包含无毛基因的同类系小鼠新品系，明确无毛基因在不同遗传背景下的表达方式。方法：将无毛基因通过杂交互交导入法分别导入615、C57BL／6、BALB／c、DBA／2共4种近交系。结果：已完成4代导入杂交的第1代、第3代均表现有毛，第2代、第4代互交育出615、C57BL／6、BALB／c、DBA／2共4种无毛小鼠，其脱毛规律同豫医无毛小鼠。结论：无毛基因可以在不同的遗传背景下表达。
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| 关 键 词： | 无毛小鼠 同类系 无毛基因 基因表达 遗传学 |
| 修稿时间： | 2001年8月13日 |
Establishment of congenic strains of hairless mice |
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| ZHANG Jintao,KANG Qiaozhen,DU Xiantang,DU Chunyan,WANG Chunyao,ZHU Qingfan Laboratory Animal Center of Henan Province,Zhengzhou.Establishment of congenic strains of hairless mice[J].Journal of Zhengzhou University: Med Sci,2002,37(2):174-176. |
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| Authors: | ZHANG Jintao KANG Qiaozhen DU Xiantang DU Chunyan WANG Chunyao ZHU Qingfan Laboratory Animal Center of Henan Province Zhengzhou |
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| Institution: | ZHANG Jintao,KANG Qiaozhen,DU Xiantang,DU Chunyan,WANG Chunyao,ZHU Qingfan Laboratory Animal Center of Henan Province,Zhengzhou 450052 |
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| Abstract: | Aim:To breed the new congenic strains of hairless mice, and study the expression of hairless gene in different hereditary backgrounds. Methods:Hairless gene was transferred into 615,C 57 BL/6,BALB/c, and DBA/2 inbred strains by cross intercross, respectively. Results:The 4th generation breeding had been accomplished. The mice of all 1st and 3rd hybrid generations all had hair and the 4 kinds of 615,C 57 BL/6,BALB/c, DBA/2 hairless mice had been bred successfully by intercrossing in the 2nd and 4th generations, whose regularity of hair losing was the same as YuYi hairless mice. Conclusion:The hairless gene can be expressed in different hereditary backgrounds. |
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| Keywords: | hairless mice congenic strain hairless gene gene expression |
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