| 河南汉族人群D7S3048基因座遗传多态性分布 |
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| 引用本文： | 孟晓峰,陈辉,孙莉,宋国英,刘华,李晓雯.河南汉族人群D7S3048基因座遗传多态性分布[J].郑州大学学报(医学版),2007,42(1):106-108. |
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| 作者姓名： | 孟晓峰 陈辉 孙莉 宋国英 刘华 李晓雯 |
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| 作者单位： | 郑州大学基础医学院细胞生物学与医学遗传学教研室,郑州,450001 |
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| 摘 要： | 目的:了解河南汉族人群中STR基因座D7S3048的遗传多态性.方法:采用PCR扩增、变性聚丙烯酰胺凝胶电泳及银染技术分析河南地区119例无血缘关系汉族人群该STR位点的遗传多态性.结果:首次获得河南汉族人群中D7S3048的分布情况.D7S3048基因座检出10个等位基因,基因型为37个,基因型频率分布符合Hardy-Weinberg平衡.汉族与蒙古族相比较,等位基因分布有差异.结论:河南地区汉族人群中D7S3048位点具有较高的多态性,在法医学和人类遗传学研究中是很好的遗传标记.
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| 关 键 词： | 河南 汉族 短串联重复序列 D7S3048 多态性 |
| 收稿时间： | 2006-04-20 |
| 修稿时间： | 2006-04-20 |
Genetic polymorphism of D7S3048 locus in Chinese Han population of Henan area |
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| MENG Xiaofeng,CHEN Hui,SUN Li,SONG Guoying,LIU Hua,LI Xiaowen.Genetic polymorphism of D7S3048 locus in Chinese Han population of Henan area[J].Journal of Zhengzhou University: Med Sci,2007,42(1):106-108. |
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| Authors: | MENG Xiaofeng CHEN Hui SUN Li SONG Guoying LIU Hua LI Xiaowen |
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| Institution: | Department of Cell Biology and Medical Genetics, College of Basic Medical Sciences, Zhengzhott University, Zhengzhou 450001 |
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| Abstract: | Aim: To investigate the genetic polymorphism at D7S3048 locus in the Han population of Henan area. Methods:The genetic polymorphism of D7S3048 locus in 119 healthy unrelated individuals of Han nationality in Henan area was analyzed,using PCR amplification, denaturing polyacrylamide gel electrophoresis(PAGE) and silver-dyed technique. Results: Ten alleles and thirty-seven genotypes were detected at D7S3048 locus. Allele frequencies were calculated and their distributions were in accordance with Hardy-Weinberg equilibrium. The allele frequency of D7S3048 locus had significant difference between Han nationality and Mongolian. Conclusion: D7S3048 locus has higher polymorphism in people of Han nationality in Henan area, which may be a very useful genetic marker for forensic medicine and population genetic research. |
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| Keywords: | Henan Han nationality short tandem repeat D7S3048 polymorphism |
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