COX-2、u-PA和TSP-1在胃癌及周围淋巴结中的表达及意义

目的:研究COX2、uPA和TSP1在胃癌及周围淋巴结中的表达状况,探讨它们在胃癌浸润和淋巴结转移中的作用和意义。方法:用组织芯片技术和免疫组化法检测COX2、uPA和TSP1的表达。结果:COX2、uPA和TSP1在胃癌组阳性表达率分别为67.7%、78.1%和78.6%,均显著高于对照组（40.0%、6.7%和40.0%,P＜0.05）。COX2表达与浸润深度有关（P＜0.05）。uPA表达与浸润深度和淋巴结转移均有关（P＜0.05）。TSP1表达与浸润深度和淋巴结转移均无关（P>0.05）。COX2、uPA和TSP1在转移淋巴结和对应癌组织间的表达差异无显著性（P>0.05）。COX2和uPA、TSP1的表达呈正相关,uPA和TSP1的表达无相关关系。结论:胃癌中COX2、uPA和TSP1高表达； COX2表达与胃癌的浸润深度有关,uPA表达与浸润深度和淋巴结转移有关。

Expression of cyclooxygenase-2,urokinase plasminogen activator and thrombospondin 1 in gastric carcinoma and surrounding peripheral lymph nodes

Objective:To investigate the expression of cyclooxygenase-2 (COX-2),urokinase plasminogen activator(u-PA),and thrombospondin-1 (TSP-1) in gastric carcinoma and the surrounding lymph nodes,so as to discuss their roles in the invasion and metastasis of gastric carcinoma.Methods:The expression of COX-2,u-PA,and TSP-1 in the samples was examined by tissue microarray and S-P immunohistochemistry staining.Results:The positive rates of COX-2,u-PA,and TSP-1 in gastric carcinoma were 67.7%,78.1%,and 78.6%,respective...