丹参大黄合剂对大鼠重症急性胰腺炎肠源性内毒素血症的治疗作用

目的探讨丹参大黄合剂对于重症急性胰腺炎肠源性内毒素血症的治疗作用。方法 Wistar大鼠随机分为假手术组、治疗组、模型组,治疗组、模型组制作重症急性胰腺炎大鼠模型,治疗组用丹参大黄合剂进行治疗干预,测定各组TNF-α、IL-6、ET、DAO水平。结果模型组血清中ET、IL-6、TNF-α、DAO明显升高,用丹参大黄合剂干预后,上述指标明显降低。结论丹参大黄合剂可以保护肠粘膜,有利于重症胰腺炎时肠源性内毒素血症的治疗。

Therapeutic effect of Mixture of Salvia miltiorrhiza and Rhubarb on Severe acute pancreatitis(SAP) intestinal endotoxemia in rats

Objective To investigate therapeutic effect of Mixture of Salvia miltiorrhiza and Rhubarb on Severe acute pancreatitis（SAP） intestinal endotoxemia.Methods Devide 30 Wistar rats into 3 groups named Sham Operation group（SO） and Model group and Theraphy group randomly and equally,set Model group and Threapy group as SAP model,intervene Theraphy group with Mixture of Salvia miltiorrhiza and Rhubarb,detect every group＇s TNF-α,IL-6,ET,DAO in blood 12 hours later.Result TNF-α,IL-6,ET,DAO of Model group is higher than SO group,but these index are lower after intervene by Mixture of Salvia miltiorrhiza and Rhubarb.Conclusion Mixture of Salvia miltiorrhiza and Rhubarb can protect Intestinal mucosa,it is benefit for treatment of Severe acute pancreatitis intestinal endotoxemia.