| 碱性成纤维细胞生长因子对慢性鼓膜穿孔愈合的影响 |
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| 引用本文： | 杜晓燕.碱性成纤维细胞生长因子对慢性鼓膜穿孔愈合的影响[J].温州医学院学报,2002,32(3):142-143. |
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| 作者姓名： | 杜晓燕 |
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| 作者单位： | 温州医学院第一附属医院耳鼻咽喉科,浙江,温州,325000 |
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| 基金项目： | 浙江省卫生厅基金项目，温州市科委 (S2 0 0 0A32 )基金项目 |
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| 摘 要： | 目的 :探讨碱性成纤维细胞生长因子 (bFGF)在慢性鼓膜穿孔愈合中的作用。方法 :在豚鼠慢性创伤性鼓膜穿孔的动物模型上 ,观察应用bFGF 磷酸缓冲液 (2 5 0mg/L)治疗的鼓膜愈合率 ,用组织学检查鼓膜中层厚度 ,并与仅用磷酸缓冲液 (PBS)处理的作对照。结果 :bFGF治疗组鼓膜愈合率明显高于PBS组 (89.3%vs 37.5 % ,P <0 .0 1) ;鼓膜中层厚度bFGF组显著高于PBS组 (30 5± 37) μmvs (10 2± 2 1) μm ,P <0 .0 1]。结论 :局部应用bFGF有明显促进慢性鼓膜穿孔鼓膜中层厚度及上皮细胞增生 ,促进鼓膜愈合的作用。
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| 关 键 词： | 鼓膜穿孔 成纤维细胞生长因子 碱性 动物实验替代实验 |
| 文章编号： | 1000-2138(2002)03-0142-02 |
| 修稿时间： | 2002年3月7日 |
The healing effect of basic fibroblast factor on the chronic tympanic membrane perforations |
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| DU Xiao-yan.The healing effect of basic fibroblast factor on the chronic tympanic membrane perforations[J].Journal of Wenzhou Medical College,2002,32(3):142-143. |
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| Authors: | DU Xiao-yan |
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| Institution: | DU Xiao-yan.Department of Otolaryngology,the First Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000 |
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| Abstract: | Objective:To evaluate the effects of basic fibroblast growth factor( bFGF) on the chronically perforated tympanic membrane.Methods:A phosphate buffer saline (PBS,pH7.4) of bFGF(250mg/L PBS) was administered to a Gelfoam pledget placed over chronic tympanic membrane perforations in guinea pigs. Control ears were treated with Gelfoam and PBS only.Results:Complete closure of the tympanic membrane perforations was observed in 89.3%(25 of 28) of bFGF-treated ears, but only 37.5%(9 of 24) in the controls(P<0.01). The middle layer of tympanic membrane treated with bFGF was obviously thicker than that with PBS only(P<0.01).Conclusion: It is suggested that basic fibroblast growth factor is effective in closing chronic tympanic membrane perforations in the guinea pigs. FK(WB80011?6] |
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| Keywords: | tympanic membrane perforation fibroblast growth factor basic animal testing alternatives |
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