| 马钱子碱对兔软骨细胞增殖的影响 |
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| 引用本文： | 张梅,李平.马钱子碱对兔软骨细胞增殖的影响[J].安徽中医学院学报,2003,22(3):39-41. |
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| 作者姓名： | 张梅 李平 |
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| 作者单位： | 安徽省立医院中医科,安徽,合肥 230001 |
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| 基金项目： | 国家中医药管理局科研项目;200-JP-58; |
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| 摘 要： | 目的：观察马钱子碱对体外培养兔软骨细胞增殖的影响。方法：分离、培养兔的软件细胞，采用四甲基偶氮唑盐比色法检测细胞增殖。结果：马钱子碱高、中、低剂量组细胞增殖率均高于空白对照组(P＜0．05)，一氧化氮(NO)能抑制软骨细胞的增殖，马钱子碱能拮抗NO对软骨细胞增殖的抑制作用。结论：马钱子碱能有效促进软骨细胞增殖。
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| 关 键 词： | 马钱子碱 兔 软骨细胞 细胞增殖 影响 一氧化氮 |
| 文章编号： | 1000-2219(2003)03-0039-02 |
| 修稿时间： | 2003年2月3日 |
Effect of Brucine on Proliferation of Rabbit Chondrocyte |
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| ZHANG Mei,LI Ping.Effect of Brucine on Proliferation of Rabbit Chondrocyte[J].Journal of Anhui Traditional Chinese Medical College,2003,22(3):39-41. |
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| Authors: | ZHANG Mei LI Ping |
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| Abstract: | Objective:To observe the effect of brucine on proliferation of chondrocyte with monolayer culture technique. Method: Rabbit chondrocytes were isolated and cultured in vitro.The cell proliferation was tested by methylthiazolyl tetrazolium (MTT) method. Result: The cell proliferation rate of high, middle and low dosage of brucine groups was higher than that of the blank control group (P<0.05). Nitric oxide could inhibit chondrocyte proliferation. Brucine could antagonize the inhibitive action of nitric oxide on chondrocyte proliferation. Conclusion: Brucine can effectively promote the proliferation of chondrocyte. |
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| Keywords: | Chondrocyte Cell proliferation Brucine Nitric oxide |
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