肝纤维化大鼠模型研究进展

肝纤维化是肝脏对各种原因所致肝损伤的创伤愈合反应,表现为肝内结缔组织增生与沉积,是慢性肝病重要的病理特征,也是进一步向肝硬化发展的重要环节.制备出标准而理想的动物模型是疾病研究的基础,选择与各种原因所致人类慢性肝病相似的肝纤维化动物模型不仅是研究肝纤维化发病机制的重要基础,也是临床评价肝纤维化诊断和治疗方法的有效手段.大鼠是肝纤维化造模的常用实验动物,本文讨论了几种肝纤维化大鼠模型的建立方法、致病机制、肝脏病理变化,每种模型的优缺点及主要用途等.

Modeling Liver Fibrosis in Rats

Liver fibrosis is the excessive accumulation of extracellular matrix proteins including collagen that occurs in most types of chronic liver diseases. Advanced liver fibrosis results in cirrhosis and liver failure. Animal models of liver fibrosis provide a means to study the cell and molecular mediators of fibrosis in a serial manner during both progression and recovery. This review summarizes several approaches to induce rats liver fibrosis. Detailed Method, pathogenesis, pathology changes of liver, advantages and disadvantages of each method and different application in research were discussed.