恒河猴Mamu-A*01基因与SIV/SHIV感染相关的研究进展

SIV/SHIV感染的恒河猴是研究艾滋病及艾滋病药物筛选、疫苗评价较理想的动物模型.MHC在细胞免疫中起着关键作用,研究表明,MHC-I类分子的多态性与SIV/SHIV感染者的疾病进展有着明显的关联作用,Mamu-A*01是恒河猴中的一种MHC-I类分子,它可以呈递特定的病毒蛋白片段到细胞的表面,从而激发CTL反应.国外发现Mamu-A*01阳性的猴艾滋病恒河猴会出现疾病进展缓慢,存活时间长等特征.本文就恒河猴Mamu-A*01基因与SIV/SHIV感染相关的研究进展做一综述,以期进一步加深对MHC在疫苗研究中的作用的了解,并促进更行之有效地对HIV/AIDS疫苗进行评价.

Progresses in Research on Mamu-A*01 Alleles and Its Association with SIV/SHIV Infection in Rhesus Macaques

Infections caused by Candida albicans can occur on the skin, on mucous surfaces, or in disseminated form throughout the body. The models on these infections have been developed in vivo and in vitro. Patterns of infection differ in inbred mice, and the variability has been shown to be genetically regulated for both experimental systems. Fortunately, the availability of gene-knockout mice has also contributed significantly to an understanding of the cellular and molecular basis of the host response. In this article, the links between the patterns of infection and the genetic factors that affected the infection was reviewed for a better elucidation on this issue.