| 米诺环素抑制小鼠肺癌生长、转移及抗血管生成的研究 |
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| 引用本文： | 黄礼年,陈余清,宋玮,承泽农,王朝夫,刘超.米诺环素抑制小鼠肺癌生长、转移及抗血管生成的研究[J].蚌埠医学院学报,2005,30(3):206-208. |
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| 作者姓名： | 黄礼年 陈余清 宋玮 承泽农 王朝夫 刘超 |
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| 作者单位： | 1. 蚌埠医学院附属医院,呼吸病科,安徽,蚌埠,233004
2. 蚌埠医学院,病理学教研室,安徽,蚌埠,233003 |
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| 基金项目： | 安徽省教育厅自然科学基金 |
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| 摘 要： | 目的:观察米诺环素(MC)对小鼠肺癌生长和转移及肿瘤血管生成的影响.方法:用T739小鼠肺癌模型,分别腹腔注射(ip)MC、环磷酰胺(CTX)、生理盐水(NS)并分成3组,检测小鼠肺癌移植瘤体积达500mm3所需时间(肿瘤生长延迟时间)、瘤重、肺转移灶数,并用免疫组化法检测血管内皮生长因子(VEGF)的表达.结果:与NS组相比,MC组小鼠肺癌移植瘤的肺转移灶数和VEGF的表达均显著降低,肿瘤生长延迟(P＜0.01);MC与CTX合用作用更为显著(P＜0.01).结论:MC可抑制小鼠肺癌移植瘤的生长和转移,其作用机制与抑制VEGF的表达、抑制血管生成有关.
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| 关 键 词： | 肺肿瘤 肿瘤转移 米诺环素 血管生成 血管内皮生长因子 小鼠 |
| 文章编号： | 1000-2200(2005)03-0206-03 |
| 修稿时间： | 2005年1月13日 |
Inhibitory effect of minocycline on the growth, metastasis and angiogenesis of lung carcinoma in mice |
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| HUANG Li-nian,CHEN Yu-qing,SONG Wei,CHENG Ze-nong,WANG Chao-fu,LIU Chao.Inhibitory effect of minocycline on the growth, metastasis and angiogenesis of lung carcinoma in mice[J].Journal of Bengbu Medical College,2005,30(3):206-208. |
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| Authors: | HUANG Li-nian CHEN Yu-qing SONG Wei CHENG Ze-nong WANG Chao-fu LIU Chao |
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| Abstract: | Objective:To investigate the effects of minocycline(MC) on the growth and metastasis of lung carcinoma and tumor angiogenesis.Methods:T739 mice with lung carcinoma were used in this study.The rats were injected MC,cyclophosphamide(CTX) or normal saline(NS).The tumor growth delay and numbers of the metastatic foci on lungs and the expression of vascular endothelial growth factor(VEGF) of lung carcinoma were observed.Results:MC remarkably reduced the numbers of the metastatic foci and the expression of VEGF of lung carcinoma,and increased the tumor growth delay(P<0.01).Conclusions:MC can obviously inhibit the growth and metastasis of lung carcinoma in mice,and its mechanism is related to the expression of VEGF and angiogenesis. |
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| Keywords: | lung neoplasms neoplasm metastasis minocycline angiogenesis vascular endothelial growth factor mice |
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