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| 三七皂苷R1、人参皂苷Rd对微循环及凝血作用的影响 | |
| 引用本文： | 陈重华,粟晓黎,张俊霞,林瑞超,颜有仪,仇学伟,童林江,陈淑杰.三七皂苷R1、人参皂苷Rd对微循环及凝血作用的影响[J].四川大学学报(医学版),2002,33(4):550-552. |
| 作者姓名： | 陈重华 粟晓黎 张俊霞 林瑞超 颜有仪 仇学伟 童林江 陈淑杰 |
| 作者单位： | 1. 四川大学华西药学院,药理学教研室,成都,610041 2. 中国药品生物制品检定所 3. 成都中医学校 4. 四川大学华西基础医学与法医学院 |
| 基金项目： | 国家重点科技攻关资助课题 (专题合同编号99-929-01-09) |
| 摘 要： | 目的研究三七皂苷R1(R1)和人参皂苷Rd(Rd)的活血化瘀作用,以证实二者为三七中的有效成分.方法显微电视放大系统定量观测R1和Rd对正常及去甲肾上腺素(NA)所致耳廓微循环障碍小鼠耳廓微循环的影响;血浆复钙试验测定R1和Rd的抗凝作用. 结果 R1和Rd能显著促进或改善正常及NA所致耳廓微循环障碍小鼠耳廓的微循环;亦可延长血浆复钙时间.结论 R1和Rd均能显著改善微循环并适度延长凝血时间,为三七中有效成分. |
| 关 键 词： | 三七皂苷R1 人参皂苷Rd 三七总皂苷 微循环 抗凝作用 |
| 修稿时间： | 2002年1月25日 |
The Effects of R1 and Rd Extracted from Panax Notoginseng Saponins on Microcirculation and Blood Coagulation |
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| Chen Chonghua ,Su Xiaoli,Zhang Junxia,Lin Ruichao,Yan Youyi,Qiu Xuewei,Tong Linjiang,Chen Shujie. West China School of Pharmacy,Sichuan University,Chengdu ,China.The Effects of R1 and Rd Extracted from Panax Notoginseng Saponins on Microcirculation and Blood Coagulation[J].Journal of West China University of Medical Sciences,2002,33(4):550-552. | |
| Authors: | Chen Chonghua Su Xiaoli Zhang Junxia Lin Ruichao Yan Youyi Qiu Xuewei Tong Linjiang Chen Shujie West China School of Pharmacy Sichuan University Chengdu China |
| Institution: | Chen Chonghua *,Su Xiaoli,Zhang Junxia,Lin Ruichao,Yan Youyi,Qiu Xuewei,Tong Linjiang,Chen Shujie. *West China School of Pharmacy,Sichuan University,Chengdu 610041,China |
| Abstract: | Objective To assess the effects of R 1 and R d extracted from panax notoginseng saponins on the promotion of blood circulation and removal of blood stasis so as to prove they are the active principle of panax notoginseng. Methods The experiment was conducted in mice. A microscopic television amplification system was used to observe quantitatively the effects of R 1 and R d on normal blood microcirculation, and on disturbed microcirculation that had been induced by auricular injection of noradrenalin; the plasma recalcification test was used to determine the effects of R 1 and R d on anticoagulation. Results It was found that R 1 and R d can obviously promote the microcirculation of normal microcirculation and improve the disturbed microcirculation. Both R 1 and R d can prolong the time of plasma recalcification. Conclusion R 1 and R d can obviously improve microcirculation and properly prolong the coagulation time, and they are the available components of panax notoginseng. |
| Keywords: | Notoginsenoside R 1 Panax notoginseng saponin R d Panax notoginseng saponins Microcirculation Anticoagulation |
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