| 蟾酥和维拉帕米镇痛协同作用的实验研究 |
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| 引用本文： | 周源,杨华中,刘英姿,张镭.蟾酥和维拉帕米镇痛协同作用的实验研究[J].湖南师范大学学报(医学版),2004,1(1):50-52. |
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| 作者姓名： | 周源 杨华中 刘英姿 张镭 |
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| 作者单位： | 湖南师范大学医学院药理教研室 |
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| 基金项目： | 湖南省教育厅资助项目 (0 2C2 30 ) |
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| 摘 要： | 目的 :研究蟾酥与维拉帕米的镇痛协同作用 ,为临床合理用药提供理论依据。方法 :采用化学刺激法、热刺激法致痛 ,观察蟾酥与维拉帕米联合应用的镇痛效果 ,用MS— 30 2系统观察蟾酥对蛙坐骨神经动作电位的影响。结果 :蟾蜍对醋酸所致小鼠腹痛、热板法致小鼠足痛均有明显的对抗作用 ,合用维拉帕米能显著增强镇痛效果 ,但蟾酥注射液对蛙坐骨神经动作电位传导无明显影响。结论 :蟾蜍和维拉帕米有镇痛协同作用
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| 关 键 词： | 蟾酥 维拉帕米 协同作用 |
| 文章编号： | 1673-016x(2004)01-0050-03 |
| 修稿时间： | 2004年9月26日 |
Synergetic Analgesic Effect of Toad Venom and Verapamil |
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| ZHOU Yuang,YANG Hua-zhong,LIU Ying-zi,ZHANG Lei.Synergetic Analgesic Effect of Toad Venom and Verapamil[J].Journal of Hunan Normal University(Medical Science),2004,1(1):50-52. |
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| Authors: | ZHOU Yuang YANG Hua-zhong LIU Ying-zi ZHANG Lei |
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| Abstract: | Objective To research synergetic analgesic effect of toad venom and verapamil. Methods Acetic acid caused body turning experiment and hot plate-induced pain experiment were used to observe analgesic effect, and the influence of action potential of toad sciatic nerve was observe by nerve chamber and multi-media MS-302 system. Results Toad venom and T-V(toad venom-verapamil) compound had remarkable analgestic effect on pain in mice induced by acetic acid and hot-plate. T-V compound had greater effect on analgesia. Verapamil has faint analgestic effect. Both toad venom and T-V compound were not able to inhibit action potential transmission of toad sciatic nerve. Conclusion Toad vonem and verapamil have analgesic synergism. |
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| Keywords: | toad vonem verapamil synergetic analgesic effect |
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