| 复方透骨草溶液抑菌和抗炎作用的实验研究 |
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| 引用本文： | 羊菲,金若敏,范斌,张宁,杨连娟,何文靖,符胜光.复方透骨草溶液抑菌和抗炎作用的实验研究[J].上海中医药杂志,2017,51(5):82-85. |
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| 作者姓名： | 羊菲 金若敏 范斌 张宁 杨连娟 何文靖 符胜光 |
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| 作者单位： | 上海中医药大学药物安全评价研究中心,上海,201203,上海中医药大学药物安全评价研究中心,上海,201203,上海中医药大学附属岳阳中西医结合医院皮肤科,上海,200437,上海中医药大学科技实验中心,上海,201203,上海市皮肤病性病医院真菌病科,上海,200050,上海市皮肤病性病医院真菌病科,上海,200050,上海中医药大学药物安全评价研究中心,上海,201203 |
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| 基金项目： | 上海市科委科研计划项目(15401972400) |
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| 摘 要： | 目的评价复方透骨草溶液的抑菌和抗炎作用,初步探索其抗炎的作用机制,为临床应用提供实验依据。方法采用体外抑菌实验,观察复方透骨草溶液对常见皮肤癣菌和酵母菌的抑制作用;采用二甲苯致小鼠耳肿胀、角叉菜胶致大鼠足趾肿胀的模型,观察复方透骨草溶液和地塞米松磷酸钠注射液外用涂抹的抗炎作用,并检测大鼠足趾致炎4 h后组织中的白细胞介素-1β(IL-1β)和肿瘤坏死因子-α(TNF-α)的水平。结果体外抑菌实验表明,复方透骨草溶液对皮肤癣菌和酵母菌的最小抑菌浓度(MIC)分别为原液浓度的12.5%和25.0%;其能降低二甲苯致小鼠耳廓的肿胀度,高剂量给药组与阴性对照组比较差异有统计学意义(P0.01);对角叉菜胶致大鼠足趾肿胀有明显的减轻作用,给药组与阴性对照组比较差异均有统计学意义(P0.01);能显著降低大鼠足趾肿胀损伤后组织中致炎因子IL-1β的表达,给药组与阴性对照组比较差异均有统计学意义(P0.05,P0.01)。结论复方透骨草溶液具有显著的抑菌和抗炎作用,并通过降低组织中的炎症因子IL-1β的水平,从而抑制炎症发展的过程。
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| 关 键 词： | 复方透骨草溶液 抑菌 抗炎 IL-1β |
| 收稿时间： | 2017/2/17 0:00:00 |
Experimental study on bacteriostatic and anti-inflammatory effects of Compound Tougucao Solution |
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| YANG Fei,JIN Ruo-min,FAN Bin,ZHANG Ning,YANG Lian-juan,HE Wen-jing and FU Sheng-guang.Experimental study on bacteriostatic and anti-inflammatory effects of Compound Tougucao Solution[J].Shanghai Journal of Traditional Chinese Medicine,2017,51(5):82-85. |
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| Authors: | YANG Fei JIN Ruo-min FAN Bin ZHANG Ning YANG Lian-juan HE Wen-jing and FU Sheng-guang |
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| Institution: | Center for Drug Safety Evaluation,Shanghai University of Traditional Chinese Medicine,Shanghai,201203,Center for Drug Safety Evaluation,Shanghai University of Traditional Chinese Medicine,Shanghai,201203,Department of Dermatology,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai,200437,Experiment Center of Science and Technology,Shanghai University of Traditional Chinese Medicine,Shanghai,201203,Department of Mycosis,Shanghai Hospital of Skin and Venereal Diseases,Shanghai,200050,Department of Mycosis,Shanghai Hospital of Skin and Venereal Diseases,Shanghai,200050 and Center for Drug Safety Evaluation,Shanghai University of Traditional Chinese Medicine,Shanghai,201203 |
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