红花提取物对高脂血症大鼠降脂和抗氧化的实验研究

目的：采用大鼠高脂血症模型观察红花提取物降血脂、抗氧化及对血液流变学指标的影响。方法：采用高脂饲料喂养大鼠造成高脂血症模型，口服给药一个月后，腹主动脉采血，分别用非抗凝血和抗凝血测定TG，TC，LDL，全血黏度，血浆黏度，红细胞压积，血清MDA，SOD和NO。结果：红花水提物明显降低高脂血症大鼠TC，TG，LDL-C；醇提物降低TC；两种提取物均降低高脂血症大鼠血浆黏度及MDA含量；醇提物使SOD活性升高。结论：红花提取物对高脂血症大鼠具有一定的降脂作用，降低血浆黏度，同时提高机体抗氧化能力。

Experimental Study on Regulation of Lipid Metabolism and Antioxidation by Extract of Carthamus Tinctorius L. in Hyperlipidemia Rat

Objective:To observe the effects of extract from Carthamus tinctorius L on regulation of lipid metabolism,hemorheological indexes,antioxidation in rat with hyperlipidemia.Methods:Using hyperlipidemia animal model replicated by hyperlipidemia forage,TC,TG,HDL,LDL,hemorheological indexes,levels of MDA,SOD,NO were assayed.Results:The levels of TG,TC,LDL-C in all groups treated with the water extract of Carthamus tinctorius L. were significantly reduced. The alcohol extract of Carthamus tinctorius L.showed a decreased action for TC and increased one for SOD activity; For the two extracts,the decreased plasma viscosity and content of MDA were found.Conclusions:The extract of Carthamus tinctorius L. regulated the lipid metabolism,improved hemorheological indexes,increased the activity of scavenging free radicals in rat with hyperlipidemia.