射干麻黄汤联合孟鲁司特治疗咳嗽变异型哮喘86例

目的:研究射干麻黄汤联合孟鲁司特治疗咳嗽变异型哮喘的临床疗效.方法:172例咳嗽变异型哮喘患者随机分为两组,对照组给予硫酸沙丁胺醇气雾剂(1喷/次,3次/d)联合酮替芬(2 mg·d-1)治疗,治疗组给予射干麻黄汤联合孟鲁司特(10 mg·d-1)口服治疗,疗程均为2周,比较两组临床有效率,评定治疗前后患者的临床症状、肺功能变化.结果:两组患者的临床症状与治疗前比较有明显改善,治疗后治疗组与对照组分别为(1.1±0.2),(1.8±0.3)分(P＜0.05)；治疗组患者呼气峰流速昼夜变异率为5.1％,明显低于对照组(9.2％)(P＜0.05)；治疗组患者临床总有效率91.9％,对照组82.6％,治疗组优于对照组(P＜0.05).结论:射干麻黄汤联合孟鲁司特治疗咳嗽变异型哮喘临床效果显著.

Montelukast Combined with Shegan Mahuang Tang for Treating of 86 Patients with Cough Variant Asthma

Objective: To study the clinical effect of montelukast combined with Shegan Mahuang Tang in treatment of cough variant asthma(CVA).Method:One hundred and seventy two patients with CVA were randomly divided into treatment group and control group,and the patients in control group were treated with salbutamol sulfate aerosol(1 dose per time,tid) combined with ketotifen(2 mg·d-1),the patients in treatment group was received with montelukast(10 mg·d-1) combined with Shegan Mahuang Tang.In two groups the treatment lasted for two weeks.Forced expiratory volume 1(FEV1),peak expiratory flow(PEF) and clinical symptom were measured,the clinical effect was compared.Result: The clinical symptom was changed by the teatments significantly.And the score in treatment group and control group was 1.1±0.2 and 1.8±0.3(P<0.05);the PEF changes of treatment group was 5.1%,it was lower than 9.2% in the control’s(P<0.05).The total effective rate of treatment group was 91.9%,and the rate of control group was 82.6%,(P<0.05).Conclusion: Shegan Mahuang Tang combined with montelukast shows satisfactory clinical efficacy in CVA,and it is worthy of clinical use.