| 反相高效液相色谱法同时测定复方环丙沙星注射液中两组分的含量 |
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| 引用本文： | 陈爱民,井明冉,刘成刚,王晋,胡志林.反相高效液相色谱法同时测定复方环丙沙星注射液中两组分的含量[J].中国药学杂志,2002,22(3):162-163. |
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| 作者姓名： | 陈爱民 井明冉 刘成刚 王晋 胡志林 |
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| 作者单位： | 1.石河子市药品检验所, 新疆 石河子 832000; 2. 石河子市人民医院，新疆 石河子832000; 3. 石河子医学院第一附属医院，新疆 石河子832000 |
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| 摘 要： | 目的：测定复方环丙沙星注射液中环丙沙星和替硝唑的含量。方法：采用反相-高效液相色谱法，色谱柱C18柱，流动相为0.4mol·L-1柠檬酸-甲醇-乙腈（2∶1∶0.8），流速为0.8 ml·min-1，检测波长为277 nm。结果：环丙沙星和替硝唑的回收率分别为99.7％和99.6%，RSD分别为0.9％和0.7％。结论：方法快速、准确，可作为该复方制剂的质量控制标准。
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| 关 键 词： | 反相-高效液相色法 环丙沙星 替硝唑 复方环丙沙星注射液 |
| 收稿时间： | 2001-04-02; |
Determination of two components in composite ciprofloxacin injection by RP-HPLC |
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| CHEN Ai-Min,JING Min-Ran,LIU Cheng-Gang,et al.Determination of two components in composite ciprofloxacin injection by RP-HPLC[J].Chinese Pharmaceutical Journal,2002,22(3):162-163. |
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| Authors: | CHEN Ai-Min JING Min-Ran LIU Cheng-Gang |
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| Institution: | Xinjiang Shiheizi Institute for Drug Control, Xinjiang Shihezi 832000 |
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| Abstract: | OBJECTIVE To determine the content of ciprofloxacin and tinizole in composite ciprofloxacin injection.METHODS An RP-HPLC method had been developed. The mobile phase was 0.4 mol·L-1 citric acid-methanol-acetonitrile (2∶1∶0.8). The flow rate was 0.8 ml·min-1. The detection wavelength was 277 nm.RESULTS The average recovery and relative standard deviation was 99.7% and 0.9% for ciprofloxacin, 99.6% and 0.7% for tinidazole respectively. CONCLUSIONS This method is rapid, simple, accurate, and suitable for the quality control of this preparation. |
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| Keywords: | RP-HPLC ciprofloxacin tinidazole composite ciprofloxacin injection |
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