| 大黄黄连泻心汤、理中丸对醋酸涂抹型胃溃疡寒、热证大鼠模型胃组织EGF、TGF-α的影响 |
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| 引用本文： | 赵伟国,李冀,柴剑波,毕珺辉,于海,蒋蕾.大黄黄连泻心汤、理中丸对醋酸涂抹型胃溃疡寒、热证大鼠模型胃组织EGF、TGF-α的影响[J].辽宁中医杂志,2012(1):49-52. |
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| 作者姓名： | 赵伟国 李冀 柴剑波 毕珺辉 于海 蒋蕾 |
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| 作者单位： | 中山大学药学院;中山大学附属中山医院;黑龙江中医药大学 |
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| 基金项目： | “十一五”国家科技支撑计划项目(2006BAI08B04-03) |
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| 摘 要： | 目的:探讨大黄黄连泻心汤、理中丸对醋酸涂抹型胃溃疡寒、热证大鼠模型的相关作用机制。方法:建立醋酸涂抹型胃溃疡寒、热证大鼠模型,ELISA法观察胃组织EGF、TGF-α的表达情况。结果:EGF的表达量在寒、热因素结合醋酸涂抹,或单纯寒、热因素结合假手术皆降低(P<0.01或P<0.05),且在病证结合模型上显著低于单纯证或病模型,但寒模与热模无显著差别(P>0.05)。TGF含量在各模型组胃组织皆降低,在病证结合模型上显著低于单纯证或病模型,但寒模与热模无显著差别。结论:热性方剂理中丸、寒性方剂大黄黄连泻心汤分别对胃溃疡寒、热证的影响体现在对应寒、热(证)模型中,具有方证相应的特点。
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| 关 键 词： | 醋酸涂抹胃溃疡 寒热证 EGF TGF-a |
Influence of Dahuang Huanglian Xiexin Decoction and Lizhong Pills on EGF TGF-a Contents in the Stomach Tissue on Acetic Acid Daub Ulcer Combined With Cold And Hot Syndrome Rats |
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| ZHAO Wei-guo,LI Ji,CHAI Jian-bo,BI Jun-hui,YU Hai,JIANG Lei.Influence of Dahuang Huanglian Xiexin Decoction and Lizhong Pills on EGF TGF-a Contents in the Stomach Tissue on Acetic Acid Daub Ulcer Combined With Cold And Hot Syndrome Rats[J].Liaoning Journal of Traditional Chinese Medicine,2012(1):49-52. |
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| Authors: | ZHAO Wei-guo LI Ji CHAI Jian-bo BI Jun-hui YU Hai JIANG Lei |
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| Institution: | 1.Sun Yat-sen University,Guangzhou 510000,Guangdong,China; 2.Zhongshan Hospital Affiliated to Sun Yat-sen University,Zhongshan 528400,Guangdong,China; 3.Heilongjiang University of Chinese Medicine,Harbin 150000,Heilongjiang,China) |
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| Abstract: | Objective:To study the mechanism and regulation of Dahuan Huanglian Xiexin Decoction and Lizhong Pill on Peptic Ulcer models with cold and hot syndrome.Methods:Estabilish acetic acid daub ulcer models with cold and hot syndrome.Detected the EGF,TGF-α in the stomach tissue.Results:Compared to the blank group,the content of EGF and TGF-α decreased in the cold syndrome and the hot syndrome.There was no difference between the two groups.Conclusion:The mechanism of the cold formulae Dahuan Huanglian Xiexin Decoction and the hot formulae Lizhong Pill embodied in different aspects. |
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| Keywords: | Acetic Acid Daub Ulcer model Cold And Hot Syndrome EGF TGF-α |
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