| 肝细胞靶向甘草次酸表面修饰脂质体的制备 |
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| 引用本文： | 毛声俊,侯世祥,金辉,张良珂,蒋彬.肝细胞靶向甘草次酸表面修饰脂质体的制备[J].中国中药杂志,2003,28(4):328-331. |
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| 作者姓名： | 毛声俊 侯世祥 金辉 张良珂 蒋彬 |
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| 作者单位： | 四川大学,华西药学院,四川,成都,610041 |
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| 基金项目： | 国家自然科学基金面上资助项目(30 2 716 13) |
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| 摘 要： | 目的 :研制靶向于肝细胞的甘草次酸表面修饰脂质体。方法 :化学合成 3-琥珀酸-30-硬脂醇甘草次酸酯 (Suc-GAOSt)作为导向分子 ,采用乙醇注入法制备甘草次酸表面修饰脂质体 (LP-SM-GA)。结果 :Suc-GAOSt确能掺入脂质膜中 ,掺入比例最高可达总脂质的9%。结论 :LP-SM-GA制备成功 ,可作为肝细胞主动靶向给药的潜在途径。
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| 关 键 词： | 甘草次酸 表面修饰 脂质体 肝细胞 |
| 文章编号： | 1001-5302(2003)0328-04 |
| 收稿时间： | 2002/10/9 0:00:00 |
| 修稿时间： | 2002年10月9日 |
Preparation of Liposomes Surface-modified with Glycyrrhetinic Acid Targeting to Hepatocytes |
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| MAO Sheng jun;HOU Shi xiang;JIN Hui;ZHANG Liang ke;JIANG Bin.Preparation of Liposomes Surface-modified with Glycyrrhetinic Acid Targeting to Hepatocytes[J].China Journal of Chinese Materia Medica,2003,28(4):328-331. |
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| Authors: | MAO Sheng jun;HOU Shi xiang;JIN Hui;ZHANG Liang ke;JIANG Bin |
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| Institution: | School of Pharmacy, Sichuan University, Chengdu 610041, Sichuan, China. |
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| Abstract: | Objective: To study the preparation of liposomes surface modified with glycyrrhetinic acid targeting to hepatocytes. Method: 3 succinic 30 stearyl glycyrrhetinic acid(Suc GAOSt), one of the amphiphilic glycyrrhetinic acid derivatives, was synthesized as targeting molecules, liposomes surface modified with glycyrrhetinic acid has been produced with ethanol injection method. Result: Targeting molecules can be mixed into the liposomal membrane. It was confirmed that the targeting molecules is 9% of the total lipids at the most in the liposomes. Conclusion: Liposomes surface modified with glycyrrhetinic acid was successfully prepared,which is considered to be a potential approach targeting to hepatocytes. |
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| Keywords: | glycyrrhetinic acid surface modification liposomes hepatocytes |
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