| 宁痫宁颗粒剂抗癫痫作用的实验研究 |
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| 引用本文： | 周大兴,金国梁,方伟.宁痫宁颗粒剂抗癫痫作用的实验研究[J].中药药理与临床,2001,17(2):29-31. |
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| 作者姓名： | 周大兴 金国梁 方伟 |
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| 作者单位： | 浙江中医学院杭州 310053 |
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| 基金项目： | 浙江省教委98资助课题 |
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| 摘 要： | 目的：研究定痫宁颗粒剂的抗癫痫作用。方法：采用海人(KA)我致癫痫、最大电休克发作（maximal electroshock seizure,MES)、戊四氮最小阈发作（metrazol minimal threshold seizure,MET)以及士的宁惊厥为指标，观察定痫宁的抗癫痫作用。结果：定痫宁能显抑制海人酸所致大鼠癫痫发作，对抗大鼠、小鼠的最大电休克发作和小鼠的戊四氮最小阈发作、士的宁的惊厥反应。结论：定痫宁具有明显的抗癫痫作用。
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| 关 键 词： | 定痛宁 癫痫 海人酸 MES MET |
Anticonvulsant action of
Dingxianning Keliji |
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| Zhou Daxing,Jing Guoliang,Fang Wei.Anticonvulsant action of
Dingxianning Keliji[J].Pharmacology and Clinics of Chinese Materia Medica,2001,17(2):29-31. |
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| Authors: | Zhou Daxing Jing Guoliang Fang Wei |
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| Abstract: | Objective: To observe the anticonvulsant action of Dingxianning Keliji (DXNKLJ). Methonds: The anticonvulsant action of DXNKLJ was investigated in Maximal Electroshock seizure (MES), Kainic acid (Ka)-induced convusion, strychine-induced convulsion, and Metrazol threshold seizure (MET), respectively. Results: DXNKLJ (24、16、8g/kg) had an obvious effect against MES in both mice or rats and MET in mice, had an antagonism tokainic acid、strychinine-induced convuision also. Conclusion: DXNKLJ had an obvious anticonvulsant effect. |
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| Keywords: | DXNKLJ kainic acid metrazol strychinine seizure |
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