| 草果知母汤在阻断PTZ点燃癫痫模型中对大鼠脑内c-fos、c-junmRNA表达的影响 |
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| 引用本文： | 张丽萍,贺娟,翟双庆,王洪图,白丽敏,梁怡.草果知母汤在阻断PTZ点燃癫痫模型中对大鼠脑内c-fos、c-junmRNA表达的影响[J].中国中西医结合杂志,2000,20(8):606-608. |
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| 作者姓名： | 张丽萍 贺娟 翟双庆 王洪图 白丽敏 梁怡 |
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| 作者单位： | 北京中医药大学!北京100029 |
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| 基金项目： | 国家中医药管理局科研基金!资助课题 (No .98Y1 1 1 ) |
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| 摘 要： | 目的：探讨草果知母汤抗痫作用的分析生物学机制。方法：选用ＳＤ大鼠以戊四唑（ＰＴＺ）诱导产生癫痫动物模型，应用分子原位杂交技术观察草果知母汤对ＰＴＺ点燃癫痫大鼠脑内ｃ－ｆｏｓ、ｃ－ｊｕｎ基因表达的影响。结果：ＰＴＺ点燃癫痫大鼠脑内ｃ－ｆｏｓ、ｃ－ｊｕｎ基因表达明显增强，草果知母汤能明显阻断其表达，并显示出良好的抗痫作用。结论：草果知母汤的抗痫作用机制可能与降低脑内ｃ－ｆｏｓ、ｃ－ｊｕｎ基因表达水平有
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| 关 键 词： | 草果知母汤 癫痫 c－fos c－jun 基因表达e |
Effect of Tsaoko-Anemarrhenae Decoction on Intracerebral c-fos, c-jun mRNA Expression in Interrupting Pentylentetrazol Kindled Epileptic Rat Model |
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| Authors: | ZHANG Liping HE Juan ZHAI Shuangqing Beijing University of Traditional Chinese Medicine Beijing |
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| Abstract: | To investigate the molecular biological mechanism of anti epileptic effect of Tsaoko Anemarrhenae decoction (TAD) on epileptic model rats. Methods: The pentylenetetrazol (PTZ) induced epileptic Sprague Dawley rats were selected as the animal model. The effects of TAD on the c fos, c jun gene expression in the rats' brain were observed by in situ hybridisation. Results: The c fos, c jun gene expression was obviously increased, TAD could effectively block the gene expression of c fos, c jun, showing better antiepileptic effect. Conclusion: The mechanism of TAD anti epileptic effect might be correlated to the decrease of c fos, c jun gene expression. |
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| Keywords: | Tsaoko Anemarrhenae decoction epilepsy c fos c jun gene expression |
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