莪术油和化疗药对照肝动脉灌注栓塞治疗原发性肝癌的临床研究 |
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引用本文: | 程剑华,常纲,吴万垠,刘伟胜,杨志钢,孟凡喆,徐凯,李柳宁,朱迪盈,陈春泳,罗海英.莪术油和化疗药对照肝动脉灌注栓塞治疗原发性肝癌的临床研究[J].中国中西医结合杂志,2001,21(3):165-167. |
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作者姓名: | 程剑华 常纲 吴万垠 刘伟胜 杨志钢 孟凡喆 徐凯 李柳宁 朱迪盈 陈春泳 罗海英 |
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作者单位: | 广东省中医医院广州 510120 |
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基金项目: | 国家“九五”中医药科技攻关课题(No.96-906-07-04)和广东省中医药管理局课题基金资助(No.97215) |
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摘 要: | 目的:评价莪术油肝动脉灌注栓塞治疗原发性肝癌的疗效、毒副作用及疗效、方法:用莪术油1-3ml经动脉插管至肝动脉灌注栓塞治疗原发性肝性32例,与同期用化疗药灌注栓塞治疗的32例作对照观察。两组均按辨证施治同时服用中药。结果:治疗组CR1例,PR13例,总有效率为43.75%,(14/32);甲胎球蛋白(AFP)转阴7例,滴度下降7例。化疗组PR10例,有效率为31.25%(10/32);AFP转阴5例,滴度下降2例,两组疗效比较差异无显著性(P>0.05)。治疗后出现灌注栓塞综合征(发热、腹痛、呕吐)病组相似;但治疗组无明显骨髓抑制现象,两组比较差异有显著性(P<0.01或P<0.05)。治疗组平均生存均生存期11.5个月,中位生存期10个月;1、2、3年生存率分别为37.5%(12/32)、13.3%(4/30)、6.9%(2/29)。化疗组平均生存期7.25个月,中位生存期6个月;1、2、3年生存率分别为15.6%(5/32)、3.2%(1/31)、0。治疗组平均生存期、中位生存期、1年生存期率均明显优于化疗组(P<0.05)。结论:莪术油肝动脉灌注全塞治疗原发性肝癌疗效与化疗药相似,但生存时间和骨髓抑制明显优于化疗药。
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关 键 词: | 莪术油 肝动脉灌注栓塞 原发性肝癌 治疗 药物疗法 |
修稿时间: | 2000年4月30日 |
A Controlled Clinical Study between Hepatic Arterial Infusion with Embolized Curcuma Aromatic Oil and Chemical Drugs in Treating Primary Liver Cancer |
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Authors: | CHENG Jian hu CHANG Gang WU Wan yin |
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Abstract: | OBJECTIVE: To evaluate the effectiveness, toxicity and prospective application of hepatic arterial infusion (HAI) with Embolized Curcuma Aromatic oil (CAO) in treating primary liver cancer (PLC). METHODS: In the treated group, 32 patients with PLC were treated by HAI with 1-3 ml of embolized CAO and oral administration of Chinese herbal medicine. In the control group, 32 patients with PLC were treated with transcatheter artery chemoembolization (TACE). RESULTS: In the treated group, one patient attained complete remission (CR) and 13 partial remission (PR), the total effective rate being 43.75%. The level of alpha fetal protein (AFP) turned to normal range in 7 cases and decreased in other 7. In the control group, 10 obtained PR and the total effective rate being 31.25%, AFP level turned to normal in 5 and decreased in 2. There was no statistical significance between the two groups. The incidences of post-embolism syndrome, such as fever, abdominal pain and vomiting were similar between the two groups but no myelosuppression occurred in the treated group with significant difference (P < 0.01) as comparing with that in the control group. The mean survival time, median survival time, 1-, 2- and 3-year survival rate in the treated group was 11.5 months, 10 months, 37.5%, 13.3% and 6.9% respectively, while in the control group was 7.25 months, 6 months, 15.6%, 3.2% and 0 respectively. The treated group was better in mean survival time, median survival time and 1-year survival rate than that of the control group (P < 0.05). CONCLUSION: HAI with embolized CAO showed a similar favorite effect in treating PLC as that of TACE, but superior than TACE with longer survival time and milder myelosuppression. |
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Keywords: | Embolized Curcuma aromatic oil infusion and embolized via hepatic artery primary liver cancer |
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