| 川芎内生真菌次级代谢产物中1个新的内酯化合物 |
| |
| 引用本文： | 李馨蕊,马川,郭力,刘娟,熊亮,周勤梅.川芎内生真菌次级代谢产物中1个新的内酯化合物[J].中草药,2019,50(20):4859-4862. |
| |
| 作者姓名： | 李馨蕊 马川 郭力 刘娟 熊亮 周勤梅 |
| |
| 作者单位： | 成都中医药大学药学院, 西南特色中药资源国家重点实验室, 四川 成都 611137;成都中医药大学, 西南特色药材创新药物成分研究所, 四川 成都 611137,成都中医药大学药学院, 西南特色中药资源国家重点实验室, 四川 成都 611137;成都中医药大学, 西南特色药材创新药物成分研究所, 四川 成都 611137,成都中医药大学药学院, 西南特色中药资源国家重点实验室, 四川 成都 611137;成都中医药大学, 西南特色药材创新药物成分研究所, 四川 成都 611137,成都中医药大学药学院, 西南特色中药资源国家重点实验室, 四川 成都 611137;成都中医药大学, 西南特色药材创新药物成分研究所, 四川 成都 611137,成都中医药大学药学院, 西南特色中药资源国家重点实验室, 四川 成都 611137;成都中医药大学, 西南特色药材创新药物成分研究所, 四川 成都 611137,成都中医药大学药学院, 西南特色中药资源国家重点实验室, 四川 成都 611137;成都中医药大学, 西南特色药材创新药物成分研究所, 四川 成都 611137 |
| |
| 基金项目： | 四川省川产道地药材综合开发与区域发展项目（2017ZY002）；四川省科技创新苗子工程培育项目（2018086，2019046）；四川省青年科技创新研究团队专项计划项目（2017TD0001，2016TD0006） |
| |
| 摘 要： | 目的研究川芎内生真菌Alternaria sp. IS275代谢产物的化学成分。方法采用硅胶和葡聚糖凝胶Sephadex LH-20柱色谱、反相中压液相色谱、制备薄层色谱以及半制备高效液相色谱等分离技术,对川芎内生真菌发酵液的醋酸乙酯提取部位进行分离纯化,利用现代波谱学手段对分离的化学成分进行结构鉴定。结果从川芎内生真菌Alternaria sp. IS275代谢产物的醋酸乙酯提取部位分离得到1个新的内酯类化合物,鉴定为(+)-4,11-二羟基-2-十二烯-5-内酯。结论化合物1为首次从川芎内真菌中分离得到的新内酯化合物,命名为芎孢内酯A。
|
| 关 键 词： | 川芎 内生真菌 次级代谢产物 新内酯化合物 芎孢内酯A |
| 收稿时间： | 2019/5/25 0:00:00 |
A new lactone from Alternaria sp. IS275, an endophytic fungus of Ligusticum chuanxiong |
| |
| LI Xin-rui,MA Chuan,GUO Li,LIU Juan,XIONG Liang and ZHOU Qin-mei.A new lactone from Alternaria sp. IS275, an endophytic fungus of Ligusticum chuanxiong[J].Chinese Traditional and Herbal Drugs,2019,50(20):4859-4862. |
| |
| Authors: | LI Xin-rui MA Chuan GUO Li LIU Juan XIONG Liang and ZHOU Qin-mei |
| |
| Institution: | State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China,State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China,State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China,State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China,State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China and State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China |
| |
| Abstract: | Objective To study the chemical constituents of metabolites of Alternaria sp. IS275, an endophytic fungus isolated from Ligusticum chuanxiong. Methods The extraction fraction of ethyl acetate from endophytic fungi fermentation broth of L. chuanxiong were isolated and purified by silica gel, Sephadex LH-20, reversed phase medium pressure chromatography, preparative TLC, and semi-preparative RP-HPLC. The structure of the separated chemical constituent was elucidated by modern spectroscopy technology. Results A new lactone compound (+)-4,11-dihydroxy-2-dodecene-5-lactone was isolated from the ethyl acetate fraction of the metabolite of Alternaria sp. IS275, an endophytic fungus of L. chuanxiong. Conclusion Compound 1 is a new lactone compound, named ligualterlide A. |
| |
| Keywords: | Ligusticum chuanxiong Hort endophytic fungi secondary metabolites new lactone compound ligualterlide A |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《中草药》浏览原始摘要信息 |
| 点击此处可从《中草药》下载免费的PDF全文 |
|
