| 龙胆苦苷的保肝作用研究 |
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| 引用本文： | 刘占文,陈长勋,金若敏,史国庆,宋纯清,胡之璧.龙胆苦苷的保肝作用研究[J].中草药,2002,33(1):47-50. |
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| 作者姓名： | 刘占文 陈长勋 金若敏 史国庆 宋纯清 胡之璧 |
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| 作者单位： | 上海中医药大学,上海,200032 |
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| 基金项目： | 国家“九五”攻关课题“龙胆苦苷质量标准的规范化研究”，批准号 96 90 30 2 0 3 |
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| 摘 要： | 目的：研究ig龙胆苦苷的肝保护作用及与龙胆草药理作用的一致性。方法：给动物ig给药，用CCl4、D－GlaN造急性肝损伤模型，测定小鼠血清ALT、AST及肝组织中谷胱甘肽过氧化物酶含量，采用麻醉大鼠，测定胆汁分泌量及胆汁成分。结果：ig龙胆苦苷后能明显降低CCl4急性肝损伤小鼠血清ALT、AST水平及增加肝组织中谷胱甘肽过氧化物酶活力，大鼠胆流量明显增加，胆汁中胆红素浓度提高。结论：龙胆苦苷具有明显肝保护作用。
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| 关 键 词： | 龙胆苦苷 保肝作用 利胆作用 中药 动物实验 |
| 文章编号： | 0253-2670(2002)01-0047-04 |
| 收稿时间： | 2001/6/12 0:00:00 |
| 修稿时间： | 2001年6月12日 |
Studies on liver-protection and promoting bile secretion of gentiopicroside |
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| LIU Zhan-wen,CHEN Chang-xun,JIN Ruo-min,SHI Guo-qing,SONG Chun-qing and HU Zhi-bi.Studies on liver-protection and promoting bile secretion of gentiopicroside[J].Chinese Traditional and Herbal Drugs,2002,33(1):47-50. |
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| Authors: | LIU Zhan-wen CHEN Chang-xun JIN Ruo-min SHI Guo-qing SONG Chun-qing and HU Zhi-bi |
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| Institution: | Shanghai University of TCM, Shanghai 200032, China;Shanghai University of TCM, Shanghai 200032, China;Shanghai University of TCM, Shanghai 200032, China;Shanghai University of TCM, Shanghai 200032, China;Shanghai University of TCM, Shanghai 200032, China;Shanghai University of TCM, Shanghai 200032, China |
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| Abstract: | Object To study the liver-protection and bile promoting secretion of gentiopicroside administrated ig in rat. Methods Gentiopicroside was administrated ig to the mice with liver injury induced by CCl 4 and D-GlaN. ALT, AST levels in serum and GSH-Px activity in liver were examined. The bile flow rate and the concentration of the main components in the bile of rats after ig administration of gentiopicroside were estimated. Results Gentiopicroside administrated ig decreased the serum ALT and AST levels, increased the liver GSH-Px activity in the mice treated with CCl 4, promoted the secretion of bile and increased the concentration of bilirubin in the bile. Conclusion Gentiopicroside administrated ig exhibited significant liver-protection and promoting bile secretion. |
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| Keywords: | gentiopicroside liver-protection promoting bile secretion |
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