| 山梨醇载体沉积法和冷冻干燥法制备番木鳖碱固体脂质体的研究 |
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| 引用本文： | 刘陶世,蔡宝昌,邓旭坤,李伟东,赵新慧,黄耀洲.山梨醇载体沉积法和冷冻干燥法制备番木鳖碱固体脂质体的研究[J].中成药,2005,27(5):509-511. |
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| 作者姓名： | 刘陶世 蔡宝昌 邓旭坤 李伟东 赵新慧 黄耀洲 |
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| 作者单位： | 南京中医药大学,江苏,南京,210029 |
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| 摘 要： | 目的:探讨番木鳖碱固体脂质体的最佳制备方法.方法:采用山梨醇载体沉积法和冷冻干燥法制备番木鳖碱固体脂质体,以外观、水溶化性、包封率、粒径大小及分布等为指标对两种方法进行比较.结果:山梨醇载体沉积法制备的番木鳖碱前体脂质体在外观和水溶化性方面不如冻干脂质体,但包封率高,粒径小而均匀,便于生产.结论:山梨醇载体沉积法制备番木鳖碱固体脂质体优于冷冻干燥法.
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| 关 键 词： | 脂质体 番木鳖碱 山梨醇 |
| 文章编号： | 1001-1528(2005)05-0509-03 |
Preparation of strychnine solid liposome by sorbitol carrier aggradation and freeze-drying method |
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| LIU Tao-shi,CAI Bao-chang,DENG Xu-kun,LI Wei-dong,ZHAO Xin-hui,HUANG Yao-zhou.Preparation of strychnine solid liposome by sorbitol carrier aggradation and freeze-drying method[J].Chinese Traditional Patent Medicine,2005,27(5):509-511. |
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| Authors: | LIU Tao-shi CAI Bao-chang DENG Xu-kun LI Wei-dong ZHAO Xin-hui HUANG Yao-zhou |
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| Abstract: | AIM: To study preparation of strychnine solid liposome. METHODS: Sorbitol carrier aggradation method and freeze drying method were used to prepare strychnine solid liposomes. They were evaluated by particle morphology, the size range, resolvable peculiarity in the water, encapsulation efficiency. RESULTS: The particles of liposome by sorbitol carrier aggradation method were less than that by freeze drying method, and its encapsulation efficiency was higher than that by freeze drying method. CONCLUSION: Sorbitol carrier aggradation method is better than freeze drying method. |
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| Keywords: | liposome strychnine freeze-drying method |
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