氯沙坦联合贝那普利治疗对高血压性心脏病患者左室舒张功能的影响

目的探讨氯沙坦联合贝那普利治疗对高血压性心脏病患者左室舒张功能的影响。方法将91例高血压性心脏病伴心功能不全患者随机分为两组，治疗组46例，每日口服氯沙坦50～100mg及贝那普利10mg，地高辛0．125～0．25mg，双氢克尿塞25mg或速尿20μg，阿斯匹林100mg。对照组45例，除无氯沙坦外余同治疗组，持续6个月。两组治疗前后检查心脏彩超测定左室舒张功能。结果治疗组左室舒张功能治疗前后比较具有显著性差异，且优于对照组（P〈0．05）。对照组治疗3个月时上述指标改变不明显（P〉0．05）。临床疗效评定：治疗组总有效率95．08％，对照组总有效率66．67％，两组比较差异有显著性（P〈0．05）。结论氯沙坦和贝那普利可抑制高血压性心脏病患者神经内分泌激活，改善左室舒张功能。

Effects of Iosartan and benazepril on cardial function in pationts with heart failure as well as Hypertension

Objective To study the effects of Losartan and Benazepril on nerve and endocrine system in patients with heart failure as well as Hypertension. Methods 91 patients with heart failune as well as Hypertension were divided into two groups randomly. One group made up of 46 patients were given Losartan 50 ～100 mg/d. Benazepril 10 mg/d. Digoxin 0. 125 - 0.25 rag/d, dihydroch lorothiazidum 25 mg/d（ or Lasix 20 mg/d） Aspirin 100 mg/d. The other group made up of 45 pationts were given Benazepril 10 mg/d. Digoxin 0. 125 - 0.25 mg/d, dihydroch lorothiazidum 25mg/d （ or Lasix 20mg/d） Aspirin 100mg/d. Results The group given Losartan and Benazepril had changed very significantly after the treatment（ P 〈 0.05 ）, and became significantly different with controls（ P 〈 0.05 ）. The evaluation on clinical therpeatic effect showed that the total effective rate of the group given Losartan and Benazepril was 95.08% ,which revealed significant differences with the to controls （66.67%）. Conclusions Losartan and benazepril can reduce the activation of nerve and endocrine system in patients with heart failure as well as Hypertension. Therefore the function of their hearts can be improved and it prompts a better prognosis.