| HIV感染者CD4+调节性T细胞与HIV DNA呈正相关 |
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| 引用本文： | 郭彩萍,画伟,计云霞,张彤,陈德喜,吴昊,焦艳梅.HIV感染者CD4+调节性T细胞与HIV DNA呈正相关[J].中国艾滋病性病,2012(1):10-13. |
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| 作者姓名： | 郭彩萍 画伟 计云霞 张彤 陈德喜 吴昊 焦艳梅 |
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| 作者单位： | 首都医科大学附属北京佑安医院感染中心 |
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| 基金项目： | 国家“十一五”传染病重大专项(2008ZX10001-006);北京市科委资助项目(D0906003040391);国家自然基金项目(30872226)~~ |
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| 摘 要： | 目的分析CD4+调节性T细胞与艾滋病病毒(HIV)脱氧核糖核酸(DNA)之间的关系。方法随机选择门诊病人50例,采用流式细胞仪细胞内染色技术检测CD4+CD2+5Foxp3+调节性T细胞的水平,并用实时定量聚合酶链反应(PCR)检测外周血单个核细胞中的DNA水平,分析CD4+调节性T细胞与CD4计数、病毒载量及HIV-1DNA之间的相关性。结果在HIV感染病人CD4+调节性T细胞与HIV DNA呈正相关,与CD4计数呈正相关,与病毒载量呈负相关。结论未进行治疗的HIV病人,其CD4+调节性T细胞与HIV DNA呈正相关,说明CD4+调节性T细胞越多,HIV-1DNA越多,CD4+调节性T细胞可能对机体发挥不利的作用。
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| 关 键 词： | 调节性T细胞 艾滋病病毒感染者 脱氧核糖核酸 |
CD4+ regulatory T cells are positively correlated with HIV DNA in HIV infected individuals |
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| Institution: | GUO Cai-ping,Hua wei,Ji Yun-xia,et al.(Department of Infectious Diseases,Beijing Youan Hospital,Capital Medical University,Beijing 100069,China) |
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| Abstract: | Objective To analyze the relationship between CD+4 regulatory T cells and HIV DNA.Methods Fifty outpatient visitors were randomly selected in Youan Hospital.Intracellular staining and flow cytometry were used to detect CD+4 CD+25 Foxp+3 regulatory T cell level,and real-time PCR quantitative method was used to detect peripheral blood mononuclear cells DNA levels.The correlation between CD+4 regulatory T cells,CD4 count,viral load and HIV-1DNA was analyzed.Result In HIV infected individuals there was positive correlation between CD+4 regulatory T cells and HIV DNA and CD4 count,but negative correlation between CD+4 regulatory T and viral load.Conclusion In the naive HIV individuals who had not received treatment,there was positive correlation between CD+4 regulatory T cells and HIVDNA,indicating that more CD+4 regulatory T cells,and more HIV-1DNA were present.Therefore,CD+4 regulatory T cells might play a negative role to the human body. |
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| Keywords: | Regulatory T cells HIV infected individals DNA |
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