前白蛋白和C反应蛋白在诊断儿童细菌性社区获得性肺炎中的临床价值

目的 探讨前白蛋白（PA）和C反应蛋白（CRP）水平对诊断儿童细菌性社区获得性肺炎（CAP）的临床价值.方法 选取2012年7月至2013年12月诊治的儿童细菌性CAP患儿72例（CAP组）,另选取同期门诊健康体检儿童50例为健康对照组.分别采用速率散射比浊法和免疫比浊法测定两组儿童血清PA和CRP,并进行比较.结果 治疗前,CAP组CRP水平显著高于健康对照组,PA水平显著低于健康对照组,差异均有统计学意义（P＜ 0.01）;CAP组白细胞计数及中性粒细胞百分比高于健康对照组,但差异无统计学意义（P＞0.05）.治疗后,CAP组CRP水平明显低于治疗前,而PA水平明显高于治疗前,差异有统计学意义（P＜0.05）.Pearson相关分析显示,CAP患儿CRP水平与PA水平呈负相关（r=-0.613,P＜0.01）.结论 测定血清PA与CRP可能有助于儿童细菌性CAP的临床诊断,对指导抗生素的使用、病情评估及疗效判断有重要参考意义.

Clinical value of prealbumin and C-reactive protein in children with bacterial community acquired pneumonia

Objective To investigate the clinical value of prealbumin （PA） and C-reactive protein （CRP） level for the diagnosis of children patients with bacterial community acquired pneumonia （CAP）.Methods Seventy-two children with bacterial CAP （CAP group） between July 2012 and December 2013 were enrolled in the study.Fifty healthy children were selected as healthy control group.The level of serum PA and CRP were measured by flow cytometry and turbidimetric immunoassay respectively.The results were compared.Results Before treatment,the level of CRP in CAP group was higher than that in healthy control group,and the level of PA in CAP group was lower than that in healthy control group,there was significant difference （P 〈 0.01）.The level of white blood cell count and the rate of neutrophilic granulocyte in CAP group was higher than that in healthy control group,but there was no significant difference（P 〉 0.05）.After treatment,the level of CRP in CAP group was decreased and the level of PA was increased,there was significant difference （P 〈 0.05）.Pearson analysis showed that the level of CRP in CAP patients had negative relationship with the level of PA （r =-0.613,P 〈 0.01）.Conclusion Detection of serum PA and CRP contributes to clinical diagnosis of children bacterial CAP and evaluation of anti-infection effect.