10％联苯菊酯水乳剂的急性毒性研究

目的研究10%联苯菊酯水乳剂的急性毒性,为其毒理安全性评价和农药的登记提供依据。方法按《农药登记毒理学试验方法(》GB15670-1995)及《农药登记资料规定(农业部2007)》进行急性经口、经皮、吸入毒性、皮肤及眼刺激试验、皮肤致敏试验。结果 10%联苯菊酯水乳剂对雌雄性SD的大鼠急性经口LD50雌、雄性均为271mg/kg b.wt.属中等毒类;对雌雄性SD大鼠急性经皮的LD50雌、雄性均为4 300mg/kg b.wt.,属低等毒类;对雌雄性SD大鼠的急性吸入LC50(2h)雌、雄性均大于5 000mg/m3,属微毒类;对雌雄性家兔的急性眼刺激性,未冲洗时急性眼刺激积分指数为6.0,平均指数为2.5,属轻度刺激性。对雌雄性家兔的急性皮肤刺激性,积分为0.0,属无刺激性。受试物原药致豚鼠致敏率为0.0%,属弱致敏物。结论 10%联苯菊酯水乳剂经口、经皮、吸入毒性分别为中低、微毒类,轻度眼刺激性、无皮肤刺激性、弱致敏性的农药。

Study On Acute Toxicity Of 10% Bifenthrin Aqueous Emulsion

Objective To study the acute toxicity of 10% bifenthrin aqueous emulsion,and provide evidence for the toxicological assessment on safety of bifenthrin aqueous emulsion and pesticide registration.Methods Based on the toxicological test methods of pesticides for registration（GB 15970-1995） and The regulation of the pesticide registration data（China Ministry of Agriculture.2007）,the acute oral toxicity test,the acute dermal toxicity test,the acute inhaling toxicity test,skin and eye irritation test,skin sensitization test were conducted.Results The LD50 of 10% bifenthrin aqueous emulsion in both male rats and female rats was 271 mg/kg b.wt.in the acute oral toxicity,4300mg/kg b.wt.in the acute dermal toxicity test,and the 2h LC50 of it exceeded 5 000mg/m3 in the acute inhaling toxicity test.So 10% bifenthrin aqueous emulsion in both male rats and female rats had mild grade toxicity by oral,and low grade toxicity by skin,and micro toxicity by inhaling.In the acute eye and skin irritation test of 10% bifenthrin aqueous emulsion in both male and female rabbits,the acute eye irritation index before washing was 6.25,and the average index was 2.5,and the acute skin irritation index was 0.0,so 10% bifenthrin aqueous emulsion had mild irritation for rabbits eye and no irritation for rabbits skin.The allergy of original drug forguinea pig was 0.0%,so this substance had weak allergy.Conclusion By the acute oral toxicity test,,the acute dermal toxicity test,the acute inhaling toxicity test,skin and eye irritation test,skin sensitization test,10% bifenthrin aqueous emulsion belongs to a kind of pesticide with middle oral toxicity,low dermal toxicity,micro inhaling toxicity,middle eye irritation,no skin irritation and weak allergy.