| 全球结核分枝杆菌谱系分布与耐药分析 |
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| 引用本文： | 王钰婷,陶必林,李忠奇,吴继周,丁洁,王建明.全球结核分枝杆菌谱系分布与耐药分析[J].中华疾病控制杂志,2022,26(11):1248-1251. |
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| 作者姓名： | 王钰婷 陶必林 李忠奇 吴继周 丁洁 王建明 |
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| 作者单位： | 1.211166 南京，南京医科大学公共卫生学院全球健康中心流行病学系 |
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| 基金项目： | 国家自然科学基金81973103江苏卫生健康委医学科研项目ZDB2020013南京市重大科技专项2021-11005 |
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| 摘 要： | 目的 绘制全球结核分枝杆菌复合群(Mycobacterium tuberculosis complex, MTBC)地理分布图，描述不同地区的MTBC主要谱系分布及耐药情况。 方法 利用TB-Profiler平台MTBC全基因组测序数据和耐药检测结果，绘制全球MTBC谱系分布图，并根据不同地域、亚谱系的层次结构进行可视化分析。 结果 Lineage 4谱系在全球分布最广，Lineage 2谱系耐药发生率最高。 结论 世界范围内MTBC谱系的地理分布及不同谱系间耐药情况存在差异。
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| 关 键 词： | 结核病 全基因组测序 结核分枝杆菌复合群 谱系 |
| 收稿时间： | 2022-03-28 |
Global geographical pedigree distribution and drug resistance of Mycobacterium tuberculosis complex |
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| Institution: | 1.Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China2.Department of Chronic Infectious Disease Prevention and Control, Nanjing Center for Disease Control and Prevention Affiliated to Nanjing Medical University, Nanjing 210003, China |
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| Abstract: | Objective To map the global geographical distribution of Mycobacterium tuberculosis complex (MTBC) and describe the main MTBC lineage and drug resistance in different regions. Methods We used the whole-genome sequencing data from the TB-profiler platform to plot the global MTBC distribution map and visualized it according to the hierarchical structure of different regions and sub-lineages. Results Lineage 4 was widely distributed worldwide, while lineage 2 had the highest risk of drug resistance. Conclusions There was a significantly different geographic distribution pattern and drug resistance of MTBC lineages worldwide. |
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