全球结核分枝杆菌谱系分布与耐药分析

王钰婷; 陶必林; 李忠奇; 吴继周; 丁洁; 王建明

doi:10.16462/j.cnki.zhjbkz.2022.11.002

全球结核分枝杆菌谱系分布与耐药分析

doi: 10.16462/j.cnki.zhjbkz.2022.11.002

1.
211166 南京，南京医科大学公共卫生学院全球健康中心流行病学系
2.
210003 南京，南京医科大学附属南京疾病预防控制中心慢性传染病防制科

基金项目:

国家自然科学基金 81973103

江苏卫生健康委医学科研项目 ZDB2020013

南京市重大科技专项 2021-11005

详细信息

通讯作者:
王建明，E-mail: jmwang@njmu.edu.cn

中图分类号: R183.3
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出版历程
- 收稿日期: 2022-03-28
- 修回日期: 2022-06-12
- 网络出版日期: 2022-12-21
- 刊出日期: 2022-11-10

Global geographical pedigree distribution and drug resistance of Mycobacterium tuberculosis complex

1.
Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China
2.
Department of Chronic Infectious Disease Prevention and Control, Nanjing Center for Disease Control and Prevention Affiliated to Nanjing Medical University, Nanjing 210003, China

Funds:

National Natural Science Foundation of China 81973103

Medical Research Project of Jiangsu Health Commission ZDB2020013

Nanjing Major Science and Technology Project 2021-11005

More Information

Corresponding author: WANG Jian-ming, E-mail: jmwang@njmu.edu.cn

摘要

摘要: 目的绘制全球结核分枝杆菌复合群(Mycobacterium tuberculosis complex, MTBC)地理分布图，描述不同地区的MTBC主要谱系分布及耐药情况。方法利用TB-Profiler平台MTBC全基因组测序数据和耐药检测结果，绘制全球MTBC谱系分布图，并根据不同地域、亚谱系的层次结构进行可视化分析。结果 Lineage 4谱系在全球分布最广，Lineage 2谱系耐药发生率最高。结论世界范围内MTBC谱系的地理分布及不同谱系间耐药情况存在差异。
- 结核病 /
- 全基因组测序 /
- 结核分枝杆菌复合群 /
- 谱系
Abstract: Objective To map the global geographical distribution of Mycobacterium tuberculosis complex (MTBC) and describe the main MTBC lineage and drug resistance in different regions. Methods We used the whole-genome sequencing data from the TB-profiler platform to plot the global MTBC distribution map and visualized it according to the hierarchical structure of different regions and sub-lineages. Results Lineage 4 was widely distributed worldwide, while lineage 2 had the highest risk of drug resistance. Conclusions There was a significantly different geographic distribution pattern and drug resistance of MTBC lineages worldwide.
- Tuberculosis /
- Whole-genome sequencing /
- Mycobacterium tuberculosis complex /
- Lineage

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图 1 MTBC分离株数目和地域分布及亚谱系构成

Figure 1. Numbers and geographical distribution of MTBC isolates and the composition of sub-lineages

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图 2 MTBC主要谱系的耐药情况

Figure 2. Distribution of drug resistance in major lineages of MTBC isolates

下载: 全尺寸图片幻灯片

表 1 根据六大洲划分的MTBC分离株特征[n(%)]

Table 1. Characteristics of MTBC isolates according to six continents [n(%)]

特征	地区						χ²值	P值^a
特征	非洲	亚洲	欧洲	北美洲	大洋洲	南美洲	χ²值	P值^a
分离株(N=29 126)	7 648(26.3)	7 047(24.2)	10 661(36.6)	1 941(6.7)	224(0.8)	1 605(5.4)
谱系分布							9 857	< 0.001
Lineage 1(L1)	384(5.0)	1 427(20.2)	722(6.8)	288(14.8)	5(2.2)	9(0.6)
Lineage 2(L2)	1 439(18.8)	3 837(54.4)	1 875(17.6)	381(19.6)	158(70.5)	94(5.9)
Lineage 3(L3)	396(5.2)	583(8.3)	1 950(18.3)	135(7.0)	5(2.2)	3(0.2)
Lineage 4(L4)	5 068(66.3)	1 198(17.0)	5 879(55.1)	1 136(58.5)	55(24.6)	1 337(83.3)
Lineage 5(L5)	207(2.7)	0(0.0)	31(0.3)	1(0.1)	0(0.0)	0(0.0)
Lineage 6(L6)	95(1.2)	0(0.0)	23(0.2)	0(0.0)	0(0.0)	0(0.0)
Lineage 7(L7)	47(0.6)	0(0.0)	1(0.0)	0(0.0)	1(0.4)	0(0.0)
Lineage 9(L9)	1(0.0)	0(0.0)	1(0.0)	0(0.0)	0(0.0)	0(0.0)
M.bovis	8(0.1)	2(0.0)	149(1.4)	0(0.0)	0(0.0)	158(9.8)
M.caprae	3(0.0)	0(0.0)	3(0.0)	0(0.0)	0(0.0)	4(0.2)
M.orygis	0(0.0)	0(0.0)	27(0.3)	0(0.0)	0(0.0)	0(0.0)
耐药类型							3 924	< 0.001
敏感	5 469(71.5)	3 408(48.4)	6 964(65.3)	1 682(86.7)	90(40.2)	191(11.9)
MDR	992(13.0)	1 204(17.1)	1 109(10.4)	25(1.3)	93(41.5)	542(33.8)
pre-MDR	549(7.2)	963(13.7)	704(6.6)	144(7.4)	28(12.5)	244(15.2)
XDR	249(3.3)	212(3.0)	429(4.0)	2(0.1)	5(2.2)	80(5.0)
pre-XDR	237(3.1)	740(10.5)	761(7.1)	6(0.3)	8(3.6)	371(23.1)
其他	152(2.0)	520(7.4)	694(6.5)	82(4.2)	0(0.0)	177(11.0)
注：^a Fisher精确概率法；牛分枝杆菌(Mycobacterium bovis，M.bovis)；山羊分枝杆菌(Mycobacterium caprae，M.caprae)；大羚羊分枝杆菌(Mycobacterium orygis，M.orygis)。

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