乳腺癌组织中survivin、c-erbB-2基因的表达与预后的关系

目的:探讨乳腺癌组织中survivin基因和c-erbB-2基因的表达与预后的关系。方法:用免疫组化S-P法检测80例乳腺癌组织中survivin、c-erbB-2的表达,分析其与腋淋巴结转移和5年无病生存率之间的关系。结果:survivin基因在乳腺癌中阳性表达率为68.75%(55/80)、c-erbB-2基因阳性表达率为36.25%(29/80),均与腋淋巴结转移正相关,与5年生存率负相关(P<0.05);survivin和c-erbB-2表达与肿瘤病理类型、发病年龄、临床分期无明显相关性(P>0.05);survivin和c-erbB-2基因表达相互呈正相关(P<0.05)。结论:凋亡抑制基因survivin和原癌基因c-erbB-2可能在乳腺癌的发生、发展过程中起重要作用,联合检测能更好地判断乳腺癌的预后。

Relationship of oncogene survivin、c-erbB-2 expression in breast cancer and its prognostic significance

Purpose:To investigate the expression of oncogene survivin,c-erbB-2 in breast cancer and its prognostic significance.Methods:Detect the expression of survivin,c-erbB-2 in 80 case breast cancer tissues by immunohistochemistry S-P method,analyze its correlation with axillary lymph node metastasis and 5-year disease free survival(DFS).Results:Survivin gene positive expression rate was 68.75%(55/80),c-erbB-2 gene positive expression rate was 36.25%(29/80) in breast cancer tissues,all have positive correlation with the axillary lymph nodes metastasis but negative to 5 years DFS(P<0.05);survivin and c-erbB-2 genes expression have no obvious correlation with the breast cancer pathology type?patient age and clinical stage(P>0.05);survivin and c-erbB-2 genes expression have positive correlation(P<0.05).Conclusions:the anti-apoptosis effect of survivin and c-erbB-2 oncogene may be important in the occurrence and advancement of breast cancer,inferring that it can be a new indicator of prognostic and judgement in breast cancer.