乳腺癌患者血清抵抗素、脂联素和瘦素水平及其临床意义

目的了解乳腺癌患者血清中抵抗素、脂联素、瘦素及血脂变化及临床意义。方法测定90例乳腺癌患者（48例未绝经,42例已绝经）及50名健康对照者血清抵抗素、脂联素、瘦素、空腹血糖（FBG）及血脂。结果乳腺癌患者脂联素及高密度脂蛋白胆固醇（HDL-C）显著低于对照组（P〈0.01或P〈0.05）,抵抗素、瘦素、FBG及三酰甘油（TG）均明显增加（P〈0.01或P〈0.05）。但抵抗素、脂联素及瘦素在未绝经乳腺癌患者与健康对照组之间差异无统计学意义（P〉0.05）。有淋巴结转移的乳腺癌患者抵抗素、脂联素及瘦素水平与无淋巴结转移乳腺癌患者间差异有统计学意义（P〈0.01）。逐步回归分析,脂联素及HDL-C的降低,瘦素和抵抗素的升高将会增加罹患乳腺癌的风险。血清脂联素降低和瘦素的增加与乳腺癌患者淋巴结的转移呈现相关性。结论血清脂联素水平的降低和抵抗素及瘦素水平的升高是患乳腺癌的危险因素。血清中较低的脂联素和较高的瘦素水平是乳腺癌转移的危险因素。

Serum levels of resistin, adiponectin and leptin in breast cancer patients and its clinical significance

Objective To investigate the change of serum levels of resistin,adiponectin and leptin in breast cancer patients and its clinical significance.Methods Blood samples were collected from 90 breast cancer patients（48 non-menopausal women and 42 menopausal women） and 50 healthy controls.Serum levels of resistin,adiponectin and leptin were determined.Fasting blood glucose（FBG） and blood lipids were assayed simultaneously.Results Serum levels of adiponectin and high-density lipoprotein cholesterol（HDL-C） were significantly decreased in the breast cancer patients in comparison to the controls（P〈0.01 and P〈0.05 respectively）.Serum levels of resistin（P〈0.01）,leptin（P〈0.01）,FBG（P〈0.01） and triglyceride（TG）in breast cancer patients were increased in contrast to the controls respectively.However,there was no significant difference of the serum levels of resistin,adiponectin and leptin between the non-menopausal breast cancer patients and the healthy controls（P〈0.05）.The serum levels of resistin,adiponectin and leptin were significantly different between patients with and without lymph node metastasis（P〈0.01）.Logistic regression analysis showed that the decreasing of adiponectin and HDL-C and the increasing of leptin and resistin would increase the risk for breast cancer.The decreasing of adiponectin and the increasing of leptin were associated with lymph node metastasis of breast cancer.Conclusions The decreased serum adiponectin levels and increased serum resistin and leptin levels are risk factors of breast cancer.The low serum adiponectin levels and high serum leptin levels are independent risk factors for the metastasis of breast cancer.