脂联素、同型半胱氨酸在退行性心瓣膜病患者中的水平变化及其临床意义

目的:探讨老年退行性心瓣膜病患者脂联素及同型半胱氨酸的水平变化及其意义。方法:选择老年退行性心瓣膜病患者80例作为观察组,健康者60例作为对照组。比较组间脂联素、同型半胱氨酸水平差异,分析其与瓣膜病变程度、瓣膜病变数量之间的关系。结果:观察组血清脂联素水平明显低于对照组(P<0.01)、同型半胱氨酸水平明显高于对照组(P<0.01);随着瓣膜病变数量增多及返流程度加重,脂联素水平进行性下降(P<0.05),同型半胱氨酸水平进行性升高(P<0.05)。结论:低脂联素血症及高同型半胱氨酸血症可能是老年退行性心瓣膜病的危险因素。

The significance of adiponectin, homocysteine in patients with degenerative heart valvular disease

Objective To investigate the levels of serum adiponectin (APN) and homocysteine (HCY) in senile patients with degenerative heart valvular disease (SDHVD). Methods Eighty patients with SDHVD were included as observe control, 60 normal controls as control group. Levels of APN and HCY were measured, and their associations with the degree and number of valvular disease were analyzed. Results Serum level of APN was significantly lover (P < 0.01) and HCY was significantly higher (P < 0.01) in observe control than those in control group. Level of APN tended to be decreased (P < 0.05), while HCY tended to be increased (P < 0.05) with the progress of the degree and number of valvular disease. Conclusions Lower level of serum APN and higher level of serum HCY may be the risk factors of SDHVD.