| 升压宁对内毒素休克肝损伤大鼠肿瘤坏死因子-α和一氧化氮合酶的影响 |
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| 引用本文： | 郑秀丽,冯全生,杨宇,张琦,乔胃娟.升压宁对内毒素休克肝损伤大鼠肿瘤坏死因子-α和一氧化氮合酶的影响[J].时珍国医国药,2009,20(12). |
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| 作者姓名： | 郑秀丽 冯全生 杨宇 张琦 乔胃娟 |
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| 作者单位： | 成都中医药大学,四川,成都,610075 |
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| 基金项目： | 四川省中医药管理局课题 |
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| 摘 要： | 目的 观察升压宁对内毒素休克肝损伤大鼠肝组织中肿瘤坏死因子-α(TNF-α)和诱导型一氧化氮合酶(iNOS)的影响.方法 采用一次性静脉注射内毒素(LPS)10 mg/kg复制内毒素休克模型,以升压宁预处理动物,并以地塞米松为阳性对照,免疫组化法测定肝组织中TNF-α和iNOS的表达.结果 内毒素休克模型组存在严重肝损伤,肝组织中TNF-α和iNOS表达较空白对照组显著增强(P﹤0.01),升压宁组肝损伤较模型组减轻,TNF-α和iNOS的表达与模型组比较显著降低(P﹤0.01).结论 升压宁能减轻内毒素休克肝损伤,其机理与抑制TNF-α和iNOS的表达有关.
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| 关 键 词： | 升压宁 内毒素休克 肝损伤 生脉散 |
The Effect of Sheng Ya Ling on TNF-α and iNOS in Liver Injury Rats with Endotoxic Shock |
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| ZHENG Xiu-li,FENG Quan-sheng,YANG Yu,ZHANG Qi,QIAO Wei-juan.The Effect of Sheng Ya Ling on TNF-α and iNOS in Liver Injury Rats with Endotoxic Shock[J].Lishizhen Medicine and Materia Medica Research,2009,20(12). |
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| Authors: | ZHENG Xiu-li FENG Quan-sheng YANG Yu ZHANG Qi QIAO Wei-juan |
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| Abstract: | Objective To explore the effect of Sheng Ya Ling on TNF-α and iNOS in liver injury rats with endotoxic shock.Methods The rats were injected intravenously LPS 10mg/kg to make endotoxic shock models. They were pre-treated by Sheng Ya Ling with the rats given dexamethasone as positive control group. Then observed the expression of TNF-a and iNOS were measured by immunohistochemical method.Results In the endotoxic shock model group, livers of rats were severely injured and the expression of TNF-α and iNOS in livers were increased more significantly than that in the blank control group(P<0.01). The liver injury of Sheng Ya Ling group was slighter than that of model group and expression of TNF-α and iNOS were decreased more significantly than that of model group(P<0.01). Conclusion Sheng Ya Ling can reduce liver injury by endotoxic and its mechanism may be with inhabitation of expression of TNF-α and iNOS. |
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| Keywords: | Sheng Ya Ling Endotoxic shock Liver injury Shengmaisan |
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