妊娠期间家长环境危险因素对儿童白血病的影响

目的 探究妊娠期间家长环境危险因素对儿童白血病的影响。方法 选取2012 年1 月-2015 年 1 月于海南医学院第一附属医院收治的白血病患儿作为白血病组，选取同期来该院进行健康检查的55 例儿童 作为对照组。单因素和Logistic 多因素分析妊娠期间家长环境危险因素对儿童白血病的影响。结果 Logistic 多因素分析结果显示，母亲接触暴露的化学物、油漆，既往流产史、孕期感冒，父亲接触暴露的柴油/ 汽油、 油漆均为儿童白血病发病的危险因素（P <0.05）。结论 把预防措施的实施提前至孕前期、孕期及新生儿期， 加强对妊娠期间家长的健康教育，降低儿童白血病的发病率。

Effect of environmental risk factors in pregnancy on incidence of childhood leukemia

Objective To explore the effect of environmental risk factors in pregnancy on the incidence of childhood leukemia. Methods Fifty-five children with leukemia in our hospital from January 2012 to January 2015 were selected as the leukemia group, and 55 children having health examination in the same period were selected as the control group. Univariate and logistic multivariate analyses were used to analyze the effect of maternal environmental risk factors on childhood leukemia. Results Logistic multivariate analysis showed that maternal exposure to chemicals and paint, previous miscarriage, cold during pregnancy, father exposure to diesel or gasoline and exposure to paint were the risk factors for childhood leukemia (P < 0.05). Conclusions Maternal exposure to chemicals, paint, past history of abortion, pregnancy cold, father exposure to diesel or gasoline, and paint are the risk factors of childhood leukemia. Therefore the health education of parents should be strengthened during pregnancy to reduce the incidence of leukemia in children.