| 黄芪注射液对腹膜透析大鼠腹膜间皮细胞水孔蛋白1表达的影响 |
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| 引用本文： | 刁金囡,盛梅笑,何伟明,朱长乐,王宁皎.黄芪注射液对腹膜透析大鼠腹膜间皮细胞水孔蛋白1表达的影响[J].广州中医药大学学报,2010,27(1):45-48,102. |
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| 作者姓名： | 刁金囡 盛梅笑 何伟明 朱长乐 王宁皎 |
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| 作者单位： | 1. 南京中医药大学附属医院肾内科,江苏南京,210029
2. 南京中医药大学附属医院,江苏南京,210029 |
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| 摘 要： | 【目的】观察黄芪注射液对腹膜透析大鼠腹膜间皮细胞水孔蛋白1（AQP—1）表达的影响。【方法】选用雄性SD大鼠25只，分正常对照组（N=7）、模型组（N=9）和黄芪组（N=9）。除正常对照组外，其他两组分别腹腔注射含42．5马／L葡萄糖的腹透液和含42．5g／L葡萄糖的愎透液＋黄芪注射液（20mg／mL），剂量为25mL／d，连续10d。于第11天观察大鼠透析超滤量（UF）与净超滤量（Net UF）、腹膜钠转运（D／P Na）、腹膜组织光镜病理形态及AQP-1免疫组化的表达．【结果】透析液留腹60min时黄芪组UF、Net UF与模型组比较显著增加（P〈0．05）。透析液留腹30min、60min时黄芪组D／P Na较模型组显著减低（P〈0．05）。黄芪组大鼠腹膜层增厚、间皮细胞脱落情况较模型组减轻，AQP—1在腹膜间皮细胞的表达较模型组显著增多（P〈0．05）【结论】黄芪注射液可减轻高浓度葡萄糖腹透液对间皮细胞的损伤，升高AQP—1在腹膜间皮细胞的表达，改善透析液留腹早期跨细胞水转运功能．从而提高腹膜对水的清除．增加透析超滤量。
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| 关 键 词： | 黄芪注射液／药理学 腹膜透析 腹膜／病理学 疾病模型，动物 大鼠 |
Effect of Astragalus Injection on Aquaporin-1 Expression of Peritoneal Mesothelial Cells in Rats with Peritoneal Dialysis |
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| DIAO Jinnan,SHENG Meixiao,HE Weiming,ZHU Changle,WANG Ningjiao.Effect of Astragalus Injection on Aquaporin-1 Expression of Peritoneal Mesothelial Cells in Rats with Peritoneal Dialysis[J].Journal of Guangzhou University of Traditional Chinese Medicine,2010,27(1):45-48,102. |
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| Authors: | DIAO Jinnan SHENG Meixiao HE Weiming ZHU Changle WANG Ningjiao |
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| Institution: | DIAO Jinnan1,SHENG Meixiao1,HE Weiming1,ZHU Changle2,WANG Ningjiao2 (1.Dept.of Nephrology,the First Affiliated Hospital,Nanjing University of TCM,Nanjing 210029 Jiangsu,China,2.The First Affiliated Hospital,China) |
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| Abstract: | Objective To observe the effect of Astragalus Injection(AI) on aquaporin-1(AQP-1) expression of peritoneal mesothelial cells in rats with peritoneal dialysis.Methods Twenty-five male SD rats were divided into the normal control group(N =7),model group(N =9) and AI group(N =9).Except the normal control group,the model group was given intraperitoneal injection of peritoneal dialysate(containing glucose 42.5 g/L),and AI group was given intraperitoneal injection of peritoneal dialysate(containing glucose 42.5 g... |
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| Keywords: | ASTRAGALUS INJECTION/pharmacology PERITONEAL DIALYSIS PERITONEUM/pathology DISEASE MODELS ANIMAL RATS |
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